2J6W
 
 | | R164N mutant of the RUNX1 Runt domain | | Descriptor: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | Authors: | Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A. | | Deposit date: | 2006-10-04 | | Release date: | 2007-10-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation.
J.Mol.Biol., 364, 2006
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2JYI
 | | Solution structure of MLL CXXC domain | | Descriptor: | ZINC ION, Zinc finger protein HRX | | Authors: | Cierpicki, T, Bushweller, J.H. | | Deposit date: | 2007-12-13 | | Release date: | 2008-12-09 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity
To be Published
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2K73
 | | Solution NMR structure of integral membrane protein DsbB | | Descriptor: | Disulfide bond formation protein B | | Authors: | Zhou, Y, Cierpicki, T, Flores Jimenez, R.H, Lukasik, S.M, Ellena, J.F, Cafiso, D.S, Kadokura, H, Beckwith, J, Bushweller, J.H. | | Deposit date: | 2008-08-01 | | Release date: | 2008-10-07 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Mol.Cell, 31, 2008
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2KNH
 | | The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide | | Descriptor: | Protein CBFA2T1, Transcription factor 12 | | Authors: | Park, S, Cierpicki, T, Tonelli, M, Bushweller, J.H. | | Deposit date: | 2009-08-25 | | Release date: | 2009-10-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood, 113, 2009
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2KKF
 | | Solution structure of MLL CXXC domain in complex with palindromic CPG DNA | | Descriptor: | 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION | | Authors: | Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H. | | Deposit date: | 2009-06-18 | | Release date: | 2009-12-08 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
Nat.Struct.Mol.Biol., 17, 2010
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2K74
 | | Solution NMR structure of DsbB-ubiquinone complex | | Descriptor: | Disulfide bond formation protein B, UBIQUINONE-2 | | Authors: | Zhou, Y, Cierpicki, T, Flores Jimenez, R.H, Lukasik, S.M, Ellena, J.F, Cafiso, D.S, Kadokura, H, Beckwith, J, Bushweller, J.H. | | Deposit date: | 2008-08-01 | | Release date: | 2008-10-07 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Mol.Cell, 31, 2008
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2KYX
 | | Solution structure of the RRM domain of CYP33 | | Descriptor: | Peptidyl-prolyl cis-trans isomerase E | | Authors: | Park, S, Bushweller, J.H. | | Deposit date: | 2010-06-09 | | Release date: | 2010-08-25 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .
Biochemistry, 49, 2010
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2N4Q
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2MV7
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2ODD
 | | Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor | | Descriptor: | Protein CBFA2T1, SMRT, ZINC ION | | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | | Deposit date: | 2006-12-22 | | Release date: | 2007-06-19 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
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2OD1
 | | Solution structure of the MYND domain from human AML1-ETO | | Descriptor: | Protein CBFA2T1, ZINC ION | | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | | Deposit date: | 2006-12-21 | | Release date: | 2007-06-19 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
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6WUW
 | | Crystal structure of Human Serum Albumin complex with JMS-053 | | Descriptor: | 1,2-ETHANEDIOL, 7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione, MYRISTIC ACID, ... | | Authors: | Czub, M.P, Cooper, D.R, Shabalin, I.G, Lazo, J.S, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-05-05 | | Release date: | 2020-05-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin.
Mol.Pharmacol., 98, 2020
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1YBO
 | | Crystal structure of the PDZ tandem of human syntenin with syndecan peptide | | Descriptor: | Syndecan-4, Syntenin 1 | | Authors: | Grembecka, J, Cooper, D.R, Cierpicki, T, Kang, B.S, Devedjiev, Y, Derewenda, Z. | | Deposit date: | 2004-12-21 | | Release date: | 2006-01-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The binding of the PDZ tandem of syntenin to target proteins
Biochemistry, 45, 2006
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2BQQ
 | | X-ray Structure of the N-terminal Domain of Human Doublecortin | | Descriptor: | NEURONAL MIGRATION PROTEIN DOUBLECORTIN | | Authors: | Kim, M.H, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | Deposit date: | 2005-04-27 | | Release date: | 2006-07-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Dc-Module of Doublecortin: Dynamics, Domain Boundaries, and Functional Implications.
Proteins, 64, 2006
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1W9E
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEFYF peptide | | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEFYF PEPTIDE | | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | Deposit date: | 2004-10-09 | | Release date: | 2006-03-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
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1W9O
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEYYV peptide | | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEYYV PEPTIDE | | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | Deposit date: | 2004-10-15 | | Release date: | 2006-03-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
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1W9Q
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEFAF peptide | | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEFAF PEPTIDE | | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, Z.S. | | Deposit date: | 2004-10-15 | | Release date: | 2006-03-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
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1V1T
 | | Crystal structure of the PDZ tandem of human syntenin in complex with TNEYKV peptide | | Descriptor: | BENZOIC ACID, SYNTENIN 1, TNEYKV PEPTIDE | | Authors: | Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | | Deposit date: | 2004-04-23 | | Release date: | 2005-06-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
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2KYG
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2N2N
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2N31
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