6V3F
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![BU of 6v3f by Molmil](/molmil-images/mine/6v3f) | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Huang, C.S, Yu, X, Min, X, Wang, Z. | Deposit date: | 2019-11-25 | Release date: | 2020-07-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition Sci Adv, 6, 2020
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6V3H
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![BU of 6v3h by Molmil](/molmil-images/mine/6v3h) | Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-D-glucopyranosiduronic acid, ... | Authors: | Huang, C.S, Yu, X, Min, X, Wang, Z. | Deposit date: | 2019-11-25 | Release date: | 2020-07-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition Sci Adv, 6, 2020
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7JR7
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![BU of 7jr7 by Molmil](/molmil-images/mine/7jr7) | Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4 | Descriptor: | ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8, Fab 11F4 heavy chain, ... | Authors: | Huang, C.S, Yu, X, Min, X, Wang, Z, Zhang, H. | Deposit date: | 2020-08-11 | Release date: | 2021-04-07 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies Commun Biol, 4, 2021
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7REW
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![BU of 7rew by Molmil](/molmil-images/mine/7rew) | Crystal Structure of IL-13 in complex with MMAb3 Fab | Descriptor: | IL13, anti-cyno interleukin 13 Fab heavy chain, anti-cyno interleukin 13 Fab light chain | Authors: | Sudom, A, Min, X. | Deposit date: | 2021-07-13 | Release date: | 2022-05-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation. J.Biol.Chem., 298, 2022
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3P4K
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![BU of 3p4k by Molmil](/molmil-images/mine/3p4k) | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution | Descriptor: | MAP kinase 14, Mitogen-activated protein kinase 14 | Authors: | Akella, R, Min, X, Wu, Q, Gardner, K.H, Goldsmith, E.J. | Deposit date: | 2010-10-06 | Release date: | 2011-01-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution Structure, 18, 2010
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5UD7
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![BU of 5ud7 by Molmil](/molmil-images/mine/5ud7) | Crystal Structure of Wild-Type Ig-like Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, SULFATE ION, ... | Authors: | Sudom, A, Min, X, Wang, Z. | Deposit date: | 2016-12-23 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.20002246 Å) | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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5UD8
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![BU of 5ud8 by Molmil](/molmil-images/mine/5ud8) | Crystal Structure of Mutant Ig-like Domain | Descriptor: | Triggering receptor expressed on myeloid cells 2 | Authors: | Sudom, A, Min, X, Wang, Z. | Deposit date: | 2016-12-23 | Release date: | 2018-04-04 | Last modified: | 2019-04-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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6CN9
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![BU of 6cn9 by Molmil](/molmil-images/mine/6cn9) | Crystal structure of the Kinase domain of WNK1 | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase WNK1 | Authors: | Akella, R, Goldsmith, E.J. | Deposit date: | 2018-03-07 | Release date: | 2019-03-27 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure, 12, 2004
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5XFJ
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![BU of 5xfj by Molmil](/molmil-images/mine/5xfj) | Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550M) | Descriptor: | 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol, Fibroblast growth factor receptor 4 | Authors: | Wu, D, Chen, Y. | Deposit date: | 2017-04-10 | Release date: | 2018-08-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. Chem. Commun. (Camb.), 54, 2018
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5IVQ
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![BU of 5ivq by Molmil](/molmil-images/mine/5ivq) | |
5IVS
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![BU of 5ivs by Molmil](/molmil-images/mine/5ivs) | |
4FF5
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![BU of 4ff5 by Molmil](/molmil-images/mine/4ff5) | |
4FFW
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![BU of 4ffw by Molmil](/molmil-images/mine/4ffw) | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin | Descriptor: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... | Authors: | Wang, Z, Sudom, A, Walker, N.P, Min, X. | Deposit date: | 2012-06-01 | Release date: | 2012-12-12 | Last modified: | 2021-05-19 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
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5X56
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![BU of 5x56 by Molmil](/molmil-images/mine/5x56) | Crystal structure of PSB27 from Arabidopsis thaliana | Descriptor: | Photosystem II repair protein PSB27-H1, chloroplastic | Authors: | Liu, J, Cheng, X. | Deposit date: | 2017-02-15 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of Psb27 from Arabidopsis thaliana determined at a resolution of 1.85 angstrom. Photosyn. Res., 136, 2018
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5XFF
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![BU of 5xff by Molmil](/molmil-images/mine/5xff) | Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550L) | Descriptor: | 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol, Fibroblast growth factor receptor 4 | Authors: | Wu, D, Chen, Y. | Deposit date: | 2017-04-10 | Release date: | 2018-09-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. Chem. Commun. (Camb.), 54, 2018
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6B8O
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![BU of 6b8o by Molmil](/molmil-images/mine/6b8o) | WT Ig-like V Domain with Phosphatidylserine | Descriptor: | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sudom, A, Wang, Z. | Deposit date: | 2017-10-09 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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4GK0
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![BU of 4gk0 by Molmil](/molmil-images/mine/4gk0) | Crystal structure of human Rev3-Rev7-Rev1 complex | Descriptor: | DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B | Authors: | Tao, J, Min, X, Wei, X. | Deposit date: | 2012-08-10 | Release date: | 2013-03-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
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4GK5
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![BU of 4gk5 by Molmil](/molmil-images/mine/4gk5) | Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex | Descriptor: | DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... | Authors: | Tao, J, Min, X, Wei, X. | Deposit date: | 2012-08-10 | Release date: | 2013-03-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
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5IVT
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![BU of 5ivt by Molmil](/molmil-images/mine/5ivt) | Crystal Structure of HIV Protease complexed with [(1S)-1-[(S)-(4-chlorophenyl)-(3,5-difluorophenyl)methyl]-2-[[5-fluoro-4-[2-[(2R,5S)-5-(2,2,2-trifluoroethylcarbamoyloxymethyl)morpholin-4-ium-2-yl]ethyl]pyridin-1-ium-3-yl]amino]-2-oxo-ethyl]ammonium | Descriptor: | (betaS)-4-chloro-beta-(3,5-difluorophenyl)-N-(5-fluoro-4-{2-[(2R,5S)-5-({[(2,2,2-trifluoroethyl)carbamoyl]oxy}methyl)morpholin-2-yl]ethyl}pyridin-3-yl)-L-phenylalaninamide, ACETATE ION, CHLORIDE ION, ... | Authors: | Su, H.P. | Deposit date: | 2016-03-21 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group. Acs Med.Chem.Lett., 7, 2016
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5IVR
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![BU of 5ivr by Molmil](/molmil-images/mine/5ivr) | |
6B3F
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![BU of 6b3f by Molmil](/molmil-images/mine/6b3f) | |
6B38
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![BU of 6b38 by Molmil](/molmil-images/mine/6b38) | |
6B3G
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![BU of 6b3g by Molmil](/molmil-images/mine/6b3g) | |
6B36
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![BU of 6b36 by Molmil](/molmil-images/mine/6b36) | |
6B3C
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![BU of 6b3c by Molmil](/molmil-images/mine/6b3c) | |