8IP6
 
 | | Cryo-EM structure of hMRS2-rest | | Descriptor: | CHLORIDE ION, Magnesium transporter MRS2 homolog, mitochondrial | | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | Deposit date: | 2023-03-14 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP3
 | | Cryo-EM structure of hMRS2-Mg | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | Deposit date: | 2023-03-14 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP4
 | | Cryo-EM structure of hMRS-highEDTA | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | Deposit date: | 2023-03-14 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8IP5
 | | Cryo-EM structure of hMRS2-lowEDTA | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | | Deposit date: | 2023-03-14 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel.
Nat Commun, 14, 2023
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8VIS
 | | Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Fraser, B.J, Dong, A, Ilyassov, O, Kenney, T, Li, Y.Y, Seitova, A, Li, Y, Hejazi, Z, Edwards, A, Benard, F, Arrowsmith, C. | | Deposit date: | 2024-01-05 | | Release date: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
To Be Published
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3IUG
 | | Crystal structure of the RhoGAP domain of RICS | | Descriptor: | Rho/Cdc42/Rac GTPase-activating protein RICS, UNKNOWN ATOM OR ION | | Authors: | Nedyalkova, L, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-08-31 | | Release date: | 2009-09-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal structure of the RhoGAP domain of RICS
to be published
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4NFB
 | | Structure of paired immunoglobulin-like type 2 receptor (PILR ) | | Descriptor: | Paired immunoglobulin-like type 2 receptor alpha | | Authors: | Lu, Q, Lu, G, Qi, J, Li, Y, Zhang, Y, Wang, H, Fan, Z, Yan, J, Gao, G. | | Deposit date: | 2013-10-31 | | Release date: | 2014-05-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NFD
 | | Structure of PILR L108W mutant in complex with sialic acid | | Descriptor: | N-acetyl-alpha-neuraminic acid, Paired immunoglobulin-like type 2 receptor beta | | Authors: | Lu, Q, Lu, G, Qi, J, Li, Y, Zhang, Y, Wang, H, Fan, Z, Yan, J, Gao, G.F. | | Deposit date: | 2013-10-31 | | Release date: | 2014-05-28 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.708 Å) | | Cite: | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid
Proc.Natl.Acad.Sci.USA, 111, 2014
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1KAR
 | | L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH HISTAMINE (INHIBITOR), ZINC AND NAD (COFACTOR) | | Descriptor: | HISTAMINE, Histidinol dehydrogenase, ZINC ION | | Authors: | Barbosa, J.A.R.G, Sivaraman, J, Li, Y, Larocque, R, Matte, A, Schrag, J.D, Cygler, M. | | Deposit date: | 2001-11-02 | | Release date: | 2002-06-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1F1Z
 | | TNSA, a catalytic component of the TN7 transposition system | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, TNSA ENDONUCLEASE | | Authors: | Hickman, A.B, Li, Y, Mathew, S.V, May, E.W, Craig, N.L, Dyda, F. | | Deposit date: | 2000-05-21 | | Release date: | 2000-06-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Unexpected structural diversity in DNA recombination: the restriction endonuclease connection.
Mol.Cell, 5, 2000
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1K75
 | | The L-histidinol dehydrogenase (hisD) structure implicates domain swapping and gene duplication. | | Descriptor: | GLYCEROL, L-histidinol dehydrogenase, SULFATE ION | | Authors: | Barbosa, J.A.R.G, Sivaraman, J, Li, Y, Larocque, R, Matte, A, Schrag, J, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | Deposit date: | 2001-10-18 | | Release date: | 2002-02-27 | | Last modified: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1KAH
 | | L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH L-HISTIDINE (PRODUCT), ZN AND NAD (COFACTOR) | | Descriptor: | HISTIDINE, Histidinol dehydrogenase, ZINC ION | | Authors: | Barbosa, J.A.R.G, Sivaraman, J, Li, Y, Larocque, R, Matte, A, Schrag, J.D, Cygler, M. | | Deposit date: | 2001-11-02 | | Release date: | 2002-06-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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7LH9
 | | Crystal structure of BRPF2 PWWP domain in complex with DNA | | Descriptor: | Bromodomain-containing protein 1, DNA | | Authors: | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-01-21 | | Release date: | 2021-02-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
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6XKK
 | | Cryo-EM structure of the NLRP1-CARD filament | | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | Deposit date: | 2020-06-26 | | Release date: | 2020-11-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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6XKJ
 | | Cryo-EM structure of CARD8-CARD filament | | Descriptor: | Caspase recruitment domain-containing protein 8 | | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | | Deposit date: | 2020-06-26 | | Release date: | 2020-11-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
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8GCY
 | | Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ... | | Authors: | Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Commun Biol, 6, 2023
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3KPX
 | | Crystal Structure Analysis of photoprotein clytin | | Descriptor: | Apophotoprotein clytin-3, C2-HYDROPEROXY-COELENTERAZINE, CALCIUM ION | | Authors: | Titushin, M.S, Li, Y, Stepanyuk, G.A, Wang, B.-C, Lee, J, Vysotski, E.S, Liu, Z.-J. | | Deposit date: | 2009-11-17 | | Release date: | 2010-10-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.899 Å) | | Cite: | NMR derived topology of a GFP-photoprotein energy transfer complex
J.Biol.Chem., 285, 2010
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5CZ3
 | | Crystal Structure of Myxoma Virus M64 | | Descriptor: | BETA-MERCAPTOETHANOL, M64R | | Authors: | Krumm, B.E, Meng, X, Li, Y, Xiang, Y, Deng, J. | | Deposit date: | 2015-07-31 | | Release date: | 2015-11-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5CYW
 | | Crystal Structure of Vaccinia Virus C7 | | Descriptor: | GLYCEROL, Interferon antagonist C7 | | Authors: | Krumm, B.E, Meng, X, Li, Y, Xiang, Y, Deng, J. | | Deposit date: | 2015-07-30 | | Release date: | 2015-11-18 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
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1JA3
 | | Crystal Structure of the Murine NK Cell Inhibitory Receptor Ly-49I | | Descriptor: | MHC class I recognition receptor Ly49I | | Authors: | Dimasi, N, Sawicki, W.M, Reineck, L.A, Li, Y, Natarajan, K, Murgulies, D.H, Mariuzza, A.R. | | Deposit date: | 2001-05-29 | | Release date: | 2002-07-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.
J.Mol.Biol., 320, 2002
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1JHN
 | | Crystal Structure of the Lumenal Domain of Calnexin | | Descriptor: | CALCIUM ION, calnexin | | Authors: | Schrag, J.D, Bergeron, J.M, Li, Y, Borisova, S, Hahn, M, Thomas, D.Y, Cygler, M. | | Deposit date: | 2001-06-28 | | Release date: | 2001-10-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Structure of calnexin, an ER chaperone involved in quality control of protein folding.
Mol.Cell, 8, 2001
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1FC4
 | | 2-AMINO-3-KETOBUTYRATE COA LIGASE | | Descriptor: | 2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE, 2-AMINO-3-KETOBUTYRIC ACID, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Schmidt, A, Matte, A, Li, Y, Sivaraman, J, Larocque, R, Schrag, J.D, Smith, C, Sauve, V, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | Deposit date: | 2000-07-17 | | Release date: | 2001-05-02 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism.
Biochemistry, 40, 2001
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7VCU
 | | Human p97 double hexamer conformer I with D1-ATPgammaS and D2-ADP bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCT
 | | Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCX
 | | Human p97 single hexamer conformer II with ATPgammaS bound | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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