7WVN
 
 | | SARS-CoV-2 Omicron S-open | | Descriptor: | Spike glycoprotein | | Authors: | Li, J.W, Cong, Y. | | Deposit date: | 2022-02-10 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis of receptor binding and antibody neutralization of Omicron.
Nature, 604, 2022
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7WVO
 | | SARS-CoV-2 Omicron S-open-2 | | Descriptor: | Spike glycoprotein | | Authors: | Li, J.W, Cong, Y. | | Deposit date: | 2022-02-10 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Molecular basis of receptor binding and antibody neutralization of Omicron.
Nature, 604, 2022
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7XLB
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8H8F
 | | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state) | | Descriptor: | Proton-activated chloride channel | | Authors: | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | | Deposit date: | 2022-10-22 | | Release date: | 2024-05-01 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA.
Cell Res., 34, 2024
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8H8E
 | | Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (closed state) | | Descriptor: | Proton-activated chloride channel, tRNA (75-MER)of Spodoptera frugiperda | | Authors: | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | | Deposit date: | 2022-10-22 | | Release date: | 2024-05-01 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA.
Cell Res., 34, 2024
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8H8D
 | | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (intermediate state) | | Descriptor: | Proton-activated chloride channel | | Authors: | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | | Deposit date: | 2022-10-22 | | Release date: | 2024-05-01 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.26 Å) | | Cite: | Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA.
Cell Res., 34, 2024
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8JKZ
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8JL0
 | | Cryo-EM structure of the prokaryotic SPARSA system complex | | Descriptor: | DNA (5'-D(P*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*T)-3'), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain protein, ... | | Authors: | Xu, X, Zhen, X, Long, F. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system.
Nat Commun, 15, 2024
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7DEG
 | | Cryo-EM structure of a heme-copper terminal oxidase dimer provides insights into its catalytic mechanism | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-[(2~{E},6~{E},10~{Z},14~{Z},18~{Z},23~{R})-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18-pentaenyl]naphthalene-1,4-dione, ... | | Authors: | Fei, S, Hartmut, M, Yun, Z, Guoliang, Z, Shuangbo, Z. | | Deposit date: | 2020-11-04 | | Release date: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | The Unusual Homodimer of a Heme-Copper Terminal Oxidase Allows Itself to Utilize Two Electron Donors.
Angew.Chem.Int.Ed.Engl., 60, 2021
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8JU6
 | | Structure of human TRPV4 with antagonist GSK279 | | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-24 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JU5
 | | Structure of human TRPV4 with antagonist A1 | | Descriptor: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-24 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVJ
 | | Structure of human TRPV4 with antagonist A2 and RhoA | | Descriptor: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVI
 | | Structure of human TRPV4 with antagonist A2 | | Descriptor: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-28 | | Release date: | 2024-05-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8K9B
 | | SARS-CoV-2 spike protein in complex with one S2H5 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of S2H5 Fab, Light chain of S2H5 Fab, ... | | Authors: | Hong, Q, Cong, Y. | | Deposit date: | 2023-07-31 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Molecular basis of SARS-CoV-2 immune evasion of NTD neutralizing antibodies.
Dian Zi Xian Wei Xue Bao, 2024
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8K9M
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8K9J
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2LWV
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2LWT
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2LX4
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8ZH6
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8ZB6
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7DK3
 | | SARS-CoV-2 S trimer, S-open | | Descriptor: | Spike glycoprotein | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2020-11-23 | | Release date: | 2020-12-16 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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7DD2
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7DK4
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7DDN
 | | SARS-Cov2 S protein at open state | | Descriptor: | Spike glycoprotein | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2020-10-29 | | Release date: | 2020-11-25 | | Last modified: | 2021-01-27 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.
Nat Commun, 12, 2021
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