4F9G
 
 | | Crystal structure of STING complex with Cyclic di-GMP. | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Transmembrane protein 173 | | Authors: | Kabaleeswaran, V, Wu, H. | | Deposit date: | 2012-05-18 | | Release date: | 2012-07-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING.
Mol.Cell, 46, 2012
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1WC1
 | | Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS | | Descriptor: | ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ADENYLATE CYCLASE, MAGNESIUM ION | | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | | Deposit date: | 2004-11-06 | | Release date: | 2004-12-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
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1WC6
 | | Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate | | Descriptor: | ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ADENYLATE CYCLASE, MAGNESIUM ION | | Authors: | Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. | | Deposit date: | 2004-11-08 | | Release date: | 2004-12-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
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4RWS
 | | Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) | | Descriptor: | C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 | | Authors: | Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) | | Deposit date: | 2014-12-05 | | Release date: | 2015-02-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.
Science, 347, 2015
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4EA3
 | | Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, ... | | Authors: | Thompson, A.A, Liu, W, Chun, E, Katritch, V, Wu, H, Vardy, E, Huang, X.P, Trapella, C, Guerrini, R, Calo, G, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | | Deposit date: | 2012-03-22 | | Release date: | 2012-04-25 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.013 Å) | | Cite: | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Nature, 485, 2012
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1XRK
 | | Crystal structure of a mutant bleomycin binding protein from Streptoalloteichus hindustanus displaying increased thermostability | | Descriptor: | BLEOMYCIN A2, Bleomycin resistance protein, SULFATE ION | | Authors: | Brouns, S.J.J, Wu, H, Akerboom, J, Turnbull, A.P, de Vos, W.M, Van der Oost, J. | | Deposit date: | 2004-10-15 | | Release date: | 2005-01-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Engineering a selectable marker for hyperthermophiles
J.Biol.Chem., 280, 2005
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4F9E
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4QQE
 | | Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, N-[2-(4-methylpiperazin-1-yl)-5-(quinolin-3-yl)phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... | | Authors: | Dong, A, Dombrovski, L, Wernimont, A, Smil, D, Getlik, M, Senisterra, G, Poda, G, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2014-06-27 | | Release date: | 2014-07-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
To be Published
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1Y2Y
 | | Structural Characterization of Nop10p using Nuclear Magnetic Resonance Spectroscopy | | Descriptor: | Ribosome biogenesis protein Nop10 | | Authors: | Khanna, M, Wu, H, Johansson, C, Caizergues-Ferrer, M, Feigon, J. | | Deposit date: | 2004-11-23 | | Release date: | 2005-12-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA
RNA, 12, 2006
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5H8O
 | | Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, VHH nanobody | | Authors: | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | | Deposit date: | 2015-12-23 | | Release date: | 2016-04-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (4.206 Å) | | Cite: | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
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3QAK
 | | Agonist bound structure of the human adenosine A2a receptor | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,lysozyme chimera | | Authors: | Xu, F, Wu, H, Katritch, V, Han, G.W, Cherezov, V, Stevens, R, GPCR Network (GPCR) | | Deposit date: | 2011-01-11 | | Release date: | 2011-03-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011
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8G17
 | | CryoEM structure of wild-type GAPDH | | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase | | Authors: | Choi, W.Y, Wu, H, Cheng, Y.F. | | Deposit date: | 2023-02-01 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (1.98 Å) | | Cite: | Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8G13
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8G12
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8G16
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8G14
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8G15
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2FUN
 | | alternative p35-caspase-8 complex | | Descriptor: | Early 35 kDa protein, caspase-8 | | Authors: | Lu, M, Min, T, Eliezer, D, Wu, H. | | Deposit date: | 2006-01-27 | | Release date: | 2006-06-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Native chemical ligation in covalent caspase inhibition by p35.
Chem.Biol., 13, 2006
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3PBF
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) complexed with glycerol | | Descriptor: | CALCIUM ION, GLYCEROL, Pulmonary surfactant-associated protein A | | Authors: | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | Deposit date: | 2010-10-20 | | Release date: | 2010-11-03 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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2EUY
 | | Solution structure of the internal loop of human U65 H/ACA snoRNA 3' hairpin | | Descriptor: | U65 box H/ACA snoRNA | | Authors: | Feigon, J, Khanna, M, Wu, H, Johansson, C, Caizergues-Ferrer, M. | | Deposit date: | 2005-10-30 | | Release date: | 2006-01-03 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA.
Rna, 12, 2006
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3OQ9
 | | Structure of the FAS/FADD death domain assembly | | Descriptor: | Protein FADD, Tumor necrosis factor receptor superfamily member 6 | | Authors: | Kabaleeswaran, V, Wu, H. | | Deposit date: | 2010-09-02 | | Release date: | 2010-10-13 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (6.8 Å) | | Cite: | The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.
Nat.Struct.Mol.Biol., 17, 2010
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3PAR
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand | | Descriptor: | CALCIUM ION, Pulmonary surfactant-associated protein A, SULFATE ION | | Authors: | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | Deposit date: | 2010-10-19 | | Release date: | 2010-11-03 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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5H8D
 | | Crystal structure of an ASC binding nanobody | | Descriptor: | VHH nanobody | | Authors: | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | | Deposit date: | 2015-12-23 | | Release date: | 2016-04-06 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
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2FW2
 | | Catalytic domain of CDY | | Descriptor: | Testis-specific chromodomain protein Y 2 | | Authors: | Min, J.R, Antoshenko, T, Wu, H, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-01-31 | | Release date: | 2006-02-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Crystal Structure of catalytic domain of Human Testis-specific chromodomain protein Y.
To be Published
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3RBN
 | | Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens] | | Descriptor: | DNA mismatch repair protein Mlh1 | | Authors: | Dong, A, Dombrovsky, L, Wernimont, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-03-29 | | Release date: | 2011-04-27 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens]
To be Published
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