8OE4
 
 | | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Bloch, Y, Felix, J, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8ODX
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8OE0
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8PPM
 | | IL-12Rb1 neutralizing Fab4, crystal kappa variant | | Descriptor: | Fab4 Light chain, crystal kappa variant, Fab4 heavy chain, ... | | Authors: | Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-07-07 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8PB1
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-06-08 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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6QI5
 | | Near Atomic Structure of an Atadenovirus Shows a possible gene duplication event and Intergenera Variations in Cementing Proteins | | Descriptor: | Hexon protein, PIIIa, Penton protein, ... | | Authors: | Condezo, G.N, Marabini, R, Gomez-Blanco, J, SanMartin, C. | | Deposit date: | 2019-01-17 | | Release date: | 2020-08-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Near-atomic structure of an atadenovirus reveals a conserved capsid-binding motif and intergenera variations in cementing proteins.
Sci Adv, 7, 2021
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7P0H
 | | Crystal structure of Helicobacter pylori ComF fused to an artificial alphaREP crystallization helper(named B2) | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, Helicobacter pylori ComF fused to an artificial alphaREP crystallization helper (named B2), ... | | Authors: | Celma, L, Walbott, H, Legrand, P, Quevillon-Cheruel, S. | | Deposit date: | 2021-06-29 | | Release date: | 2022-04-06 | | Last modified: | 2022-04-27 | | Method: | X-RAY DIFFRACTION (2.499 Å) | | Cite: | ComFC mediates transport and handling of single-stranded DNA during natural transformation.
Nat Commun, 13, 2022
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6TN3
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8BI2
 | | Syk kinase domain in complex with macrocyclic inhibitor 20a | | Descriptor: | 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK | | Authors: | Read, J.A, Patel, J. | | Deposit date: | 2022-11-01 | | Release date: | 2023-06-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.508 Å) | | Cite: | Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg.Med.Chem.Lett., 91, 2023
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8CIQ
 | | JzTx-34 toxin peptide | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-10 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CJP
 | | JzTx-34 toxin peptide H18A mutant | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-13 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CJS
 | | JzTx-34 toxin peptide W31A mutant | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-13 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CJQ
 | | JzTx-34 toxin peptide E20A mutant | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-13 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CJR
 | | JzTx-34 toxin peptide W25A mutant | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-13 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CJT
 | | JzTx-34 toxin peptide W33A mutant | | Descriptor: | Mu-theraphotoxin-Cg1a | | Authors: | Landon, C, Meudal, H. | | Deposit date: | 2023-02-13 | | Release date: | 2023-07-26 | | Method: | SOLUTION NMR | | Cite: | Structure-function relationship of new peptides activating human Na v 1.1.
Biomed Pharmacother, 165, 2023
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8CBQ
 | | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | | Deposit date: | 2023-01-25 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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8CBN
 | | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | | Deposit date: | 2023-01-25 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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7AYY
 | | Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... | | Authors: | Masuyer, G, Davies, J.R, Stenmark, P. | | Deposit date: | 2020-11-13 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
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7AYZ
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7AZ0
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8PEP
 | | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Koutna, E, Kouba, T, Veverka, V. | | Deposit date: | 2023-06-14 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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8PC5
 | | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Koutna, E, Kouba, T, Veverka, V. | | Deposit date: | 2023-06-09 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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8PEO
 | | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex | | Descriptor: | (2R)-2-amino-3-(2-dimethylaminoethylsulfanyl)propanoic acid, Histone H2A, Histone H2B 1.1, ... | | Authors: | Koutna, E, Kouba, T, Veverka, V. | | Deposit date: | 2023-06-14 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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8PC6
 | | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Koutna, E, Kouba, T, Veverka, V. | | Deposit date: | 2023-06-09 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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6SPF
 | | Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | | Deposit date: | 2019-09-01 | | Release date: | 2019-10-23 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate.
Proc.Natl.Acad.Sci.USA, 116, 2019
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