5MXA

Structure of unbound Interleukin-23

Summary for 5MXA

Entry DOI	10.2210/pdb5mxa/pdb
Descriptor	Interleukin-23 subunit alpha, Interleukin-12 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	cytokine, extracellular, inflammation, fibronectin type iii
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	59827.50
Authors	Bloch, Y.,Savvides, S.N. (deposition date: 2017-01-22, release date: 2017-12-20, Last modification date: 2024-01-17)
Primary citation	Bloch, Y.,Bouchareychas, L.,Merceron, R.,Skladanowska, K.,Van den Bossche, L.,Detry, S.,Govindarajan, S.,Elewaut, D.,Haerynck, F.,Dullaers, M.,Adamopoulos, I.E.,Savvides, S.N. Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1. Immunity, 48:45-58.e6, 2018 Cited by PubMed: 29287995 DOI: 10.1016/j.immuni.2017.12.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.501 Å)

Structure validation