6VOV
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![BU of 6vov by Molmil](/molmil-images/mine/6vov) | Crystal structure of Syk in complex with GS-9876 | Descriptor: | 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine, Tyrosine-protein kinase SYK | Authors: | Lansdon, E.B. | Deposit date: | 2020-01-31 | Release date: | 2020-03-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. Acs Med.Chem.Lett., 11, 2020
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6VT2
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5WWU
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![BU of 5wwu by Molmil](/molmil-images/mine/5wwu) | Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | Authors: | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2017-01-05 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.794 Å) | Cite: | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio, 9, 2018
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4NQJ
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![BU of 4nqj by Molmil](/molmil-images/mine/4nqj) | Structure of coiled-coil domain | Descriptor: | DODECYL-BETA-D-MALTOSIDE, E3 ubiquitin-protein ligase TRIM69 | Authors: | Yang, M, Li, Y. | Deposit date: | 2013-11-25 | Release date: | 2014-05-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.152 Å) | Cite: | Structural insights into the TRIM family of ubiquitin E3 ligases. Cell Res., 24, 2014
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7FJ1
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![BU of 7fj1 by Molmil](/molmil-images/mine/7fj1) | Cryo-EM structure of pseudorabies virus C-capsid | Descriptor: | Capsid vertex component 1, DNA packaging tegument protein UL25, Major capsid protein, ... | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | Deposit date: | 2021-08-02 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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7FJ3
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![BU of 7fj3 by Molmil](/molmil-images/mine/7fj3) | Cryo-EM structure of PRV A-capid | Descriptor: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | Authors: | Zheng, Q, Li, S, Zha, Z, Sun, H. | Deposit date: | 2021-08-02 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (4.53 Å) | Cite: | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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5KIQ
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![BU of 5kiq by Molmil](/molmil-images/mine/5kiq) | SrpA with sialyl LewisX | Descriptor: | ACETATE ION, CALCIUM ION, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Iverson, T.M. | Deposit date: | 2016-06-16 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.638 Å) | Cite: | Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry, 2016
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6X3K
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6X3Q
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4R83
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![BU of 4r83 by Molmil](/molmil-images/mine/4r83) | Crystal structure of Sialyltransferase from Photobacterium damsela | Descriptor: | CALCIUM ION, Sialyltransferase 0160 | Authors: | Fisher, A.J, Chen, X, Li, Y, Huynh, N. | Deposit date: | 2014-08-29 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae. Febs Lett., 588, 2014
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4R9V
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![BU of 4r9v by Molmil](/molmil-images/mine/4r9v) | Crystal structure of sialyltransferase from photobacterium damselae, residues 113-497 corresponding to the gt-b domain | Descriptor: | CALCIUM ION, Sialyltransferase 0160 | Authors: | Li, Y, Huynh, N, Chen, X, Fisher, A.J. | Deposit date: | 2014-09-08 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae. Febs Lett., 588, 2014
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4R84
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![BU of 4r84 by Molmil](/molmil-images/mine/4r84) | Crystal structure of Sialyltransferase from Photobacterium damsela with CMP-3F(a)Neu5Ac bound | Descriptor: | CALCIUM ION, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, Sialyltransferase 0160 | Authors: | Fisher, A.J, Chen, X, Li, Y, Huynh, N. | Deposit date: | 2014-08-29 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae. Febs Lett., 588, 2014
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7FAH
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![BU of 7fah by Molmil](/molmil-images/mine/7fah) | Immune complex of head region of CA09 HA and neutralizing antibody 12H5 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Li, T.T, Xue, W.H, Gu, Y, Li, S.W. | Deposit date: | 2021-07-06 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.151 Å) | Cite: | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
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4RHR
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![BU of 4rhr by Molmil](/molmil-images/mine/4rhr) | Crystal structure of PltB | Descriptor: | ACETATE ION, Putative pertussis-like toxin subunit | Authors: | Gao, X, Wang, J, Galan, J. | Deposit date: | 2014-10-02 | Release date: | 2014-10-29 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (2.079 Å) | Cite: | Host adaptation of a bacterial toxin from the human pathogen salmonella typhi. Cell(Cambridge,Mass.), 159, 2014
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4RHS
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![BU of 4rhs by Molmil](/molmil-images/mine/4rhs) | Crystal structure of GD2 bound PltB | Descriptor: | ACETATE ION, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, Putative pertussis-like toxin subunit | Authors: | Gao, X, Wang, J, Galan, J. | Deposit date: | 2014-10-02 | Release date: | 2014-10-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9211 Å) | Cite: | Host adaptation of a bacterial toxin from the human pathogen salmonella typhi. Cell(Cambridge,Mass.), 159, 2014
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3PCD
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![BU of 3pcd by Molmil](/molmil-images/mine/3pcd) | PROTOCATECHUATE 3,4-DIOXYGENASE Y447H MUTANT | Descriptor: | BETA-MERCAPTOETHANOL, CARBONATE ION, FE (III) ION, ... | Authors: | Orville, A.M, Lipscomb, J.D, Ohlendorf, D.H. | Deposit date: | 1997-11-24 | Release date: | 1998-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The axial tyrosinate Fe3+ ligand in protocatechuate 3,4-dioxygenase influences substrate binding and product release: evidence for new reaction cycle intermediates. Biochemistry, 37, 1998
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6K7O
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![BU of 6k7o by Molmil](/molmil-images/mine/6k7o) | Complex structure of LILRB4 and h128-3 antibody | Descriptor: | Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain | Authors: | Song, H, Chai, Y, Xu, X, Gao, F.G. | Deposit date: | 2019-06-08 | Release date: | 2019-07-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development. Cancer Immunol Res, 7, 2019
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7END
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7EN9
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![BU of 7en9 by Molmil](/molmil-images/mine/7en9) | Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-02 | Descriptor: | 3C-like proteinase, 5-bromanyl-~{N}-methyl-3-nitro-2-[(4~{R},5~{S})-2-(7-oxidanylisoquinolin-4-yl)carbonyl-4-phenyl-2,7-diazaspiro[4.4]nonan-7-yl]benzamide | Authors: | Hou, N, Peng, C, Hu, Q. | Deposit date: | 2021-04-16 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7EN8
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![BU of 7en8 by Molmil](/molmil-images/mine/7en8) | Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-04 | Descriptor: | 3C-like proteinase, GLYCEROL, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide | Authors: | Hou, N, Peng, C, Hu, Q. | Deposit date: | 2021-04-16 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7ENE
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2DWU
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![BU of 2dwu by Molmil](/molmil-images/mine/2dwu) | Crystal Structure of Glutamate Racemase Isoform RacE1 from Bacillus anthracis | Descriptor: | D-GLUTAMIC ACID, GLYCEROL, Glutamate racemase, ... | Authors: | Mehboob, S, Santarsiero, B.D, Johnson, M.E. | Deposit date: | 2006-08-17 | Release date: | 2007-06-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for Inhibitor Design J.Mol.Biol., 371, 2007
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2PE0
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![BU of 2pe0 by Molmil](/molmil-images/mine/2pe0) | CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE, GLYCEROL, ... | Authors: | Whitlow, M, Adler, M. | Deposit date: | 2007-04-01 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity. Bioorg.Med.Chem.Lett., 17, 2007
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2PE1
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![BU of 2pe1 by Molmil](/molmil-images/mine/2pe1) | CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) {2-Oxo-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-2,3-dihydro-1H-indol-5-yl}-urea {BX-517} COMPLEX | Descriptor: | 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ... | Authors: | Whitlow, M, Adler, M. | Deposit date: | 2007-04-01 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity. Bioorg.Med.Chem.Lett., 17, 2007
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6CKM
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