6IWT
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8FOW
| Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib | Descriptor: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... | Authors: | Schonbrunn, E, Sun, L. | Deposit date: | 2023-01-03 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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8FP5
| CDK2 liganded with ATP and Mg2+ | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclin-dependent kinase 2, ... | Authors: | Schonbrunn, E, Sun, L. | Deposit date: | 2023-01-04 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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8FP0
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8H4I
| DHA-bound FFAR4 in complex with Gs | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4L
| DHA-bound FFAR4 in complex with Gq | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8H4K
| GW9508-bound FFAR4 in complex with Gq | Descriptor: | 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2022-10-10 | Release date: | 2023-06-21 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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7D4G
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7DX4
| The structure of FC08 Fab-hA.CE2-RBD complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Heavy chain of FC08 Fab, ... | Authors: | Cao, L, Wang, X. | Deposit date: | 2021-01-18 | Release date: | 2021-04-21 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2. Natl Sci Rev, 8, 2021
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8IYS
| TUG891-bound FFAR4 in complex with Gq | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | He, Y, Yin, H. | Deposit date: | 2023-04-06 | Release date: | 2023-06-21 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8IFO
| Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter | Descriptor: | DNA (5'-D(*GP*AP*GP*GP*AP*CP*AP*AP*AP*GP*GP*TP*GP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*CP*AP*CP*CP*TP*TP*TP*GP*TP*CP*CP*TP*C)-3'), Estrogen-related receptor gamma, ... | Authors: | Xu, T, Zhen, X, Liu, J. | Deposit date: | 2023-02-19 | Release date: | 2023-03-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element. Biochem.Biophys.Res.Commun., 656, 2023
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7DVB
| D335N variant of Bt4394 in complex with 6SO3-NAG-oxazoline intermediate | Descriptor: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, [(3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-2-methyl-6,7-bis(oxidanyl)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]oxazol-1-ium-5-yl]methyl sulfate | Authors: | Zhang, Z, He, Y, Jin, Y. | Deposit date: | 2021-01-13 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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7DUP
| Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | Authors: | Zhang, Z, He, Y, Jin, Y. | Deposit date: | 2021-01-10 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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7DVA
| Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc | Descriptor: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, GLYCEROL | Authors: | Zhang, Z, He, Y, Jin, Y. | Deposit date: | 2021-01-13 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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2MKX
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7ENO
| Mutant strain M3 of foot-and-mouth disease virus type O | Descriptor: | VP1 of O type FMDV capsid, VP2 of O type FMDV capsid, VP3 of O type FMDV capsid, ... | Authors: | Dong, H, Lu, Y. | Deposit date: | 2021-04-18 | Release date: | 2021-06-02 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity. J.Virol., 95, 2021
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7ENP
| wild type of O type Foot-and-mouth disease virus | Descriptor: | VP1 of O type FMDV capsid protein, VP2 of O type FMDV capsid protein, VP3 of O type FMDV capsid protein, ... | Authors: | Dong, H, Lu, Y. | Deposit date: | 2021-04-18 | Release date: | 2021-06-02 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity. J.Virol., 95, 2021
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3R8B
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4MKI
| Cobalt transporter ATP-binding subunit | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Energy-coupling factor transporter ATP-binding protein EcfA2, SULFATE ION | Authors: | Yu, Y, Zhang, L, Chai, C.L, Heymann, D. | Deposit date: | 2013-09-05 | Release date: | 2013-10-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for a homodimeric ATPase subunit of an ECF transporter Protein Cell, 4, 2013
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6J8F
| Crystal structure of SVBP-VASH1 with peptide mimic the C-terminal of alpha-tubulin | Descriptor: | 8-mer peptide, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-18 | Release date: | 2019-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.283 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6J8N
| Crystal structure of SVBP-VASH1 complex, mutation C169A of VASH1 | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-20 | Release date: | 2019-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6J9H
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6JOM
| Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae | Descriptor: | 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, Lipoate--protein ligase | Authors: | Zhang, H, Chen, H, Ma, G. | Deposit date: | 2019-03-22 | Release date: | 2020-03-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae. Front Cell Infect Microbiol, 10, 2020
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6J91
| Structure of a hypothetical protease | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liao, S, Gao, J, Xu, C. | Deposit date: | 2019-01-21 | Release date: | 2019-06-19 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6LI1
| Crystal structure of GPR52 ligand free form with flavodoxin fusion | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera of G-protein coupled receptor 52 and Flavodoxin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | Deposit date: | 2019-12-10 | Release date: | 2020-02-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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