4ROV
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![BU of 4rov by Molmil](/molmil-images/mine/4rov) | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C. | Deposit date: | 2014-10-29 | Release date: | 2014-12-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem., 290, 2015
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4ROW
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![BU of 4row by Molmil](/molmil-images/mine/4row) | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C. | Deposit date: | 2014-10-29 | Release date: | 2014-12-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem., 290, 2015
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5Y93
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![BU of 5y93 by Molmil](/molmil-images/mine/5y93) | Crystal Structure Analysis of the BRD4 | Descriptor: | 1,2-ETHANEDIOL, 2-[[5-[(5-bromanyl-2-methoxy-phenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-(2-morpholin-4-ylethyl)ethanamide, Bromodomain-containing protein 4, ... | Authors: | Xu, Y, Zhang, Y, Song, M, Wang, C. | Deposit date: | 2017-08-22 | Release date: | 2018-06-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61, 2018
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5Z1T
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![BU of 5z1t by Molmil](/molmil-images/mine/5z1t) | Crystal Structure Analysis of the BRD4(1) | Descriptor: | 1,2-ETHANEDIOL, 5-bromo-N-(6-hydroxy-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-2-methoxybenzene-1-sulfonamide, Bromodomain-containing protein 4, ... | Authors: | Xu, Y, Zhang, Y, Xiang, Q, Song, M, Wang, C. | Deposit date: | 2017-12-28 | Release date: | 2019-01-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. Acs Med.Chem.Lett., 9, 2018
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4QU2
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![BU of 4qu2 by Molmil](/molmil-images/mine/4qu2) | The structure of JMJD7 with alpha-KG | Descriptor: | 2-OXOGLUTARIC ACID, JmjC domain-containing protein 7, NICKEL (II) ION | Authors: | Liu, H.L, Wang, C, Zhang, G.Y. | Deposit date: | 2014-07-10 | Release date: | 2015-07-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of JMJD7 with alpha-KG To be Published
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2YYF
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![BU of 2yyf by Molmil](/molmil-images/mine/2yyf) | Purification and structural characterization of a D-amino acid containing conopeptide, marmophine, from Conus marmoreus | Descriptor: | M-conotoxin mr12 | Authors: | Huang, F, Du, W, Han, Y, Wang, C. | Deposit date: | 2007-04-29 | Release date: | 2008-04-08 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. Febs J., 275, 2008
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4RWS
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![BU of 4rws by Molmil](/molmil-images/mine/4rws) | Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) | Descriptor: | C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 | Authors: | Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) | Deposit date: | 2014-12-05 | Release date: | 2015-02-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 2015
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4NC3
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![BU of 4nc3 by Molmil](/molmil-images/mine/4nc3) | Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHOLESTEROL, ... | Authors: | Liu, W, Wacker, D, Gati, C, Han, G.W, James, D, Wang, D, Nelson, G, Weierstall, U, Katritch, V, Barty, A, Zatsepin, N.A, Li, D, Messerschmidt, M, Boutet, S, Williams, G.J, Koglin, J.E, Seibert, M.M, Wang, C, Shah, S.T.A, Basu, S, Fromme, R, Kupitz, C, Rendek, K.N, Grotjohann, I, Fromme, P, Kirian, R.A, Beyerlein, K.R, White, T.A, Chapman, H.N, Caffrey, M, Spence, J.C.H, Stevens, R.C, Cherezov, V, GPCR Network (GPCR) | Deposit date: | 2013-10-23 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Serial femtosecond crystallography of G protein-coupled receptors. Science, 342, 2013
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4ZA1
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![BU of 4za1 by Molmil](/molmil-images/mine/4za1) | Crystal Structure of NosA Involved in Nosiheptide Biosynthesis | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, NosA | Authors: | Liu, S, Guo, H, Zhang, T, Han, L, Yao, P, Zhang, Y, Rong, N, Yu, Y, Lan, W, Wang, C, Ding, J, Wang, R, Liu, W, Cao, C. | Deposit date: | 2015-04-13 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Sci Rep, 5, 2015
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8E3H
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![BU of 8e3h by Molmil](/molmil-images/mine/8e3h) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-17 | Release date: | 2022-09-07 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E6Z
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![BU of 8e6z by Molmil](/molmil-images/mine/8e6z) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E5O
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![BU of 8e5o by Molmil](/molmil-images/mine/8e5o) | Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-22 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E3F
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![BU of 8e3f by Molmil](/molmil-images/mine/8e3f) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-17 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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7V1U
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![BU of 7v1u by Molmil](/molmil-images/mine/7v1u) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12 | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide | Authors: | Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y. | Deposit date: | 2021-08-06 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia. Acta Pharmacol.Sin., 43, 2022
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8E5K
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![BU of 8e5k by Molmil](/molmil-images/mine/8e5k) | Escherichia coli Rho-dependent transcription pre-termination complex containing 21 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-22 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E5P
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![BU of 8e5p by Molmil](/molmil-images/mine/8e5p) | Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-22 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E6W
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![BU of 8e6w by Molmil](/molmil-images/mine/8e6w) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, lambda-tR1 rut RNA, Mg-ADP-BeF3, and NusG; Rho part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E6X
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![BU of 8e6x by Molmil](/molmil-images/mine/8e6x) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, lambda-tR1 rut RNA, Mg-ADP-BeF3, and NusG; TEC part | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E70
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![BU of 8e70 by Molmil](/molmil-images/mine/8e70) | Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E5L
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![BU of 8e5l by Molmil](/molmil-images/mine/8e5l) | Escherichia coli Rho-dependent transcription pre-termination complex containing 21 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-22 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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7V2J
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![BU of 7v2j by Molmil](/molmil-images/mine/7v2j) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33 | Descriptor: | Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-4-methoxy-benzenesulfonamide | Authors: | Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y. | Deposit date: | 2021-08-09 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia. Acta Pharmacol.Sin., 43, 2022
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4X9Z
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![BU of 4x9z by Molmil](/molmil-images/mine/4x9z) | Dimeric conotoxin alphaD-GeXXA | Descriptor: | alphaD-conotoxin GeXXA from the venom of Conus generalis | Authors: | Xu, S, Zhang, T, Kompella, S, Adams, D, Ding, J, Wang, C. | Deposit date: | 2014-12-12 | Release date: | 2015-12-02 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conotoxin alpha D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Sci Rep, 5, 2015
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2XIG
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![BU of 2xig by Molmil](/molmil-images/mine/2xig) | The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites | Descriptor: | CITRIC ACID, FERRIC UPTAKE REGULATION PROTEIN, ZINC ION | Authors: | Dian, C, Vitale, S, Leonard, G.A, Fauquant, F, Muller, C, Bahlawane, C, de Reuse, H, Michaud-Soret, I, Terradot, L. | Deposit date: | 2010-06-29 | Release date: | 2011-01-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Structure of the Helicobacter Pylori Ferric Uptake Regulator Fur Reveals Three Functional Metal Binding Sites. Mol.Microbiol., 79, 2011
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1YM0
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![BU of 1ym0 by Molmil](/molmil-images/mine/1ym0) | Crystal Structure of Earthworm Fibrinolytic Enzyme Component B: a Novel, Glycosylated Two-chained Trypsin | Descriptor: | MAGNESIUM ION, SULFATE ION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, F, Wang, C, Li, M, Zhang, J.P, Gui, L.L, An, X.M, Chang, W.R. | Deposit date: | 2005-01-20 | Release date: | 2005-04-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal structure of earthworm fibrinolytic enzyme component B: a novel, glycosylated two-chained trypsin. J.Mol.Biol., 348, 2005
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6MRO
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![BU of 6mro by Molmil](/molmil-images/mine/6mro) | Crystal structure of methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution, Northeast Structural Genomics Consortium (NESG) Target MvR53. | Descriptor: | CALCIUM ION, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Singh, S, Forouhar, F, Wang, C, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2018-10-15 | Release date: | 2018-10-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a methyl transferase from Methanosarcina acetivorans at 1.6 Angstroms resolution. To Be Published
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