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6WXL
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BU of 6wxl by Molmil
Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer
Descriptor: 1D12 Light chain, 1D21 Heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2020-05-11
Release date:2021-06-09
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.
Structure, 2022
6XF5
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BU of 6xf5 by Molmil
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (RBDs down)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-06-15
Release date:2020-09-02
Last modified:2020-12-02
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
SSRN, 2020
6XRT
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BU of 6xrt by Molmil
Cryo-EM structure of SHIV-elicited RHA1.V2.01 in complex with HIV-1 Env BG505 DS-SOSIP.664
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2020-07-13
Release date:2020-10-07
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Science, 371, 2021
6X78
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BU of 6x78 by Molmil
Vaccine-elicited mouse FP-targeting neutralizing antibody vFP48.03 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide 512-519 V2, SULFATE ION, antibody vFP48.03 heavy chain, ...
Authors:Xu, K, Kwong, P.D.
Deposit date:2020-05-29
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.359 Å)
Cite:Distinct Classes of HIV-1 Cross-Clade Neutralizing Antibodies Targeting Fusion Peptide Elicited in Mice by Diverse Immunization Regimens
To Be Published
6X7W
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BU of 6x7w by Molmil
Vaccine-elicited mouse FP-targeting neutralizing antibody vFP49.02 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide 512-519, SULFATE ION, antibody vFP49.02 heavy chain, ...
Authors:Xu, K, Kwong, P.D.
Deposit date:2020-05-30
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Distinct Classes of HIV-1 Cross-Clade Neutralizing Antibodies Targeting Fusion Peptide Elicited in Mice by Diverse Immunization Regimens
To Be Published
6XSK
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BU of 6xsk by Molmil
Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 789-203-3C12 Fab Heavy Chain, ...
Authors:Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-07-15
Release date:2021-07-21
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Immunity, 55, 2022
6WIX
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BU of 6wix by Molmil
Crystal Structure of HIV-1 MI369 RnS-DS.SOSIP Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, Y.-T, Olia, A, Kwong, P.D.
Deposit date:2020-04-10
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
Cell Rep, 33, 2020
6XF6
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BU of 6xf6 by Molmil
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD up)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-06-15
Release date:2020-09-02
Last modified:2020-12-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
SSRN, 2020
4JHA
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BU of 4jha by Molmil
Crystal Structure of RSV-Neutralizing Human Antibody D25
Descriptor: D25 antigen-binding fragment heavy chain, D25 light chain
Authors:Mclellan, J.S, Chen, M, Leung, S, Graepel, K.W, Du, X, Yang, Y, Zhou, T, Baxa, U, Yasuda, E, Beaumont, T, Kumar, A, Modjarrad, K, Zheng, Z, Zhao, M, Xia, N, Kwong, P.D, Graham, B.S.
Deposit date:2013-03-04
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4JAN
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BU of 4jan by Molmil
crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ...
Authors:Zhou, T, Moquin, S, Zheng, A, Srivatsan, S, Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013
4JHW
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BU of 4jhw by Molmil
Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25
Descriptor: D25 antigen-binding fragment heavy chain, D25 light chain, Fusion glycoprotein F0
Authors:Mclellan, J.S, Chen, M, Leung, S, Graepel, K.W, Du, X, Yang, Y, Zhou, T, Baxa, U, Yasuda, E, Beaumont, T, Kumar, A, Modjarrad, K, Zheng, Z, Zhao, M, Xia, N, Kwong, P.D, Graham, B.S.
Deposit date:2013-03-05
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4JPV
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BU of 4jpv by Molmil
Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Zhou, T, Moquin, S, Kwong, P.D.
Deposit date:2013-03-19
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.827 Å)
Cite:Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.
Cell(Cambridge,Mass.), 153, 2013
4KA2
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BU of 4ka2 by Molmil
Crystal structure of CD4-mimetic miniprotein M48U12 in complex with HIV-1 YU2 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 YU2 gp120, M48U12
Authors:Acharya, P, Kwong, P.D.
Deposit date:2013-04-21
Release date:2013-06-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Interfacial Cavity Filling To Optimize CD4-Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein.
J.Med.Chem., 56, 2013
5IQ7
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BU of 5iq7 by Molmil
Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.
Descriptor: 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide
Authors:Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
Deposit date:2016-03-10
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2869 Å)
Cite:Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
4K0A
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BU of 4k0a by Molmil
Crystal structure of CD4-mimetic miniprotein M48U7 in complex with HIV-1 YU2 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-MIMETIC MINIPROTEIN M48U7, CITRATE ANION, ...
Authors:Acharya, P, Kwong, P.D.
Deposit date:2013-04-03
Release date:2013-06-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
Structure, 21, 2013
5I8H
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BU of 5i8h by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.664 gp120, ...
Authors:Xu, K, Zhou, T, Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
8T1G
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BU of 8t1g by Molmil
The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11
Descriptor: 1E11 Fab Heavy chain, 1E11 Fab Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2023-06-02
Release date:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11
To Be Published
8TE7
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BU of 8te7 by Molmil
Structure of TRNM-f.01
Descriptor: TRNM-f.01 Fab Heavy Chain, TRNM-f.01 Fab Light Chain
Authors:Bender, M.F, Olia, A.S, Kwong, P.D.
Deposit date:2023-07-05
Release date:2024-07-10
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Broad and Potent HIV-1 Neutralization in Fusion Peptide-primed SHIV-boosted Macaques
To Be Published
8TDX
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BU of 8tdx by Molmil
TRNM-b.01 in complex with HIV Env fusion peptide
Descriptor: Env Fusion Peptide, TRNM-b.01 Fab Heavy Chain, TRNM-b.01 Fab Light Chain
Authors:Olia, A.S, Kwong, P.D.
Deposit date:2023-07-05
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Broad and potent HIV-1 neutralization in fusion peptide-primed SHIV-boosted macaques
To Be Published
5I8E
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BU of 5i8e by Molmil
Crystal Structure of Broadly Neutralizing HIV-1 Fusion Peptide-Targeting Antibody VRC34.01 Fab
Descriptor: VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, ZINC ION
Authors:Xu, K, Zhou, T, Liu, K, Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.655 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
5JO5
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BU of 5jo5 by Molmil
Crystal structure of 10E8 gHV-gLV antigen-binding fragment.
Descriptor: 10E8 gHV, 10E8 gLV
Authors:Joyce, M.G, Mascola, J.R, Kwong, P.D.
Deposit date:2016-05-02
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
Plos One, 11, 2016
4LAJ
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BU of 4laj by Molmil
Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOHEXANOIC ACID, ...
Authors:Acharya, P, Luongo, T.S, Kwong, P.D.
Deposit date:2013-06-20
Release date:2013-08-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites.
J.Virol., 87, 2013
6BF4
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BU of 6bf4 by Molmil
Crystal Structure of HIV-1 Clade AE Strain CNE55 gp120 Core in Complex with Neutralizing Antibody VRC-PG05 that Targets the Center of the Silent Face on the Outer Domain of gp120
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2017-10-25
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.
Immunity, 48, 2018
5IQ9
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BU of 5iq9 by Molmil
Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide.
Descriptor: 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide
Authors:Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
Deposit date:2016-03-10
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
4JAM
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BU of 4jam by Molmil
Crystal structure of broadly neutralizing anti-hiv-1 antibody ch103
Descriptor: 1,2-ETHANEDIOL, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ...
Authors:Zhou, T, Moquin, S, Zheng, A, Srivatsan, S, Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013

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