9XZM

Cryo-EM structure of F-box helicase 1 (FBH1) bound to an SCF ubiquitin ligase complex and a 3-way DNA fork (substrate structure)

Summary for 9XZM

• Entry DOI: 10.2210/pdb9xzm/pdb
• Related: 9XZJ 9XZK 9XZL
• EMDB information: 72362
• Descriptor: DNA (45-MER), DNA (5'-D(*TP*CP*GP*CP*TP*AP*CP*CP*TP*TP*CP*GP*CP*AP*GP*TP*C)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*GP*CP*TP*TP*CP*CP*AP*TP*CP*GP*CP*TP*GP*TP*CP*TP*AP*G)-3'), ... (8 entities in total)
• Functional Keywords: helicase, translocase, fork remodeler, fork reversal, replication fork, dna binding, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 150024.33

Authors

Mullins, E.A.,Schiltz, C.J.,Eichman, B.F. (deposition date: 2025-08-27, release date: 2026-01-28)

• Primary citation: Greer, B.H.,Mendia Garcia, J.,Mullins, E.A.,Peacock, E.M.,Haigh, S.,Schiltz, C.J.,Tsai, M.-S.,Cortez, D.,Moreno-Herrero, F.,Eichman, B.F.; F-box helicase 1 reverses replication forks through assembly on the lagging strand template at the fork junction; To Be Published,

Experimental method

ELECTRON MICROSCOPY (10.27 Å)