9XZK

Cryo-EM structure of F-box helicase 1 (FBH1) bound to an SCF ubiquitin ligase complex and a 3-way DNA fork (head structure)

Summary for 9XZK

• Entry DOI: 10.2210/pdb9xzk/pdb
• Related: 9XZJ 9XZL 9XZM
• EMDB information: 72359
• Descriptor: Cullin-1, E3 ubiquitin-protein ligase RBX1 (2 entities in total)
• Functional Keywords: helicase, translocase, fork remodeler, fork reversal, replication fork, dna binding, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 102090.28

Authors

Mullins, E.A.,Schiltz, C.J.,Eichman, B.F. (deposition date: 2025-08-27, release date: 2026-01-28)

• Primary citation: Greer, B.H.,Mendia Garcia, J.,Mullins, E.A.,Peacock, E.M.,Haigh, S.,Schiltz, C.J.,Tsai, M.-S.,Cortez, D.,Moreno-Herrero, F.,Eichman, B.F.; F-box helicase 1 reverses replication forks through assembly on the lagging strand template at the fork junction; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.91 Å)