6O0G

M.tb MenD bound to Intermediate I and Inhibitor

Summary for 6O0G

• Entry DOI: 10.2210/pdb6o0g/pdb
• Related: 5ERX 5ERY 5ESD 5ESS 5ESU 6O04
• Descriptor: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, 1,4-dihydroxy-2-naphthoic acid, ... (11 entities in total)
• Functional Keywords: menaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, mend, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 4
• Total formula weight: 243222.09

Authors

Johnston, J.M.,Bashiri, G.,Bulloch, E.M.M.,Jirgis, E.M.N.,Chuang, H.,Nigon, L.V.,Baker, E.N. (deposition date: 2019-02-16, release date: 2020-02-19, Last modification date: 2023-10-11)

• Primary citation: Bashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M.; Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.; J.Biol.Chem., 295:3759-3770, 2020; PubMed: 32029475; DOI: 10.1074/jbc.RA119.012158

Experimental method

X-RAY DIFFRACTION (2.4 Å)