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6I01

Structure of human D-glucuronyl C5 epimerase in complex with substrate

Summary for 6I01
Entry DOI10.2210/pdb6i01/pdb
Related6HZZ 6I02
DescriptorD-glucuronyl C5-epimerase, CALCIUM ION, beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ... (11 entities in total)
Functional Keywordsc5-epimerase, heparan sulfate, isomerase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight129442.74
Authors
Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Le Narvor, C.,Goulet, A.,Fadel, F.,Vives, R.R.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y. (deposition date: 2018-10-24, release date: 2019-04-03, Last modification date: 2024-01-24)
Primary citationDebarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Delauzun, V.,Le Narvor, C.,Richard, E.,Henault, J.,Goulet, A.,Fadel, F.,Vives, R.R.,Priem, B.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y.
Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.
Proc.Natl.Acad.Sci.USA, 116:6760-6765, 2019
Cited by
PubMed: 30872481
DOI: 10.1073/pnas.1818333116
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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