6I01
Structure of human D-glucuronyl C5 epimerase in complex with substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0047464 | molecular_function | heparosan-N-sulfate-glucuronate 5-epimerase activity |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0047464 | molecular_function | heparosan-N-sulfate-glucuronate 5-epimerase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30872481, ECO:0007744|PDB:6I01 |
| Chain | Residue | Details |
| A | TYR180 | |
| A | ARG563 | |
| A | ASN572 | |
| B | TYR180 | |
| B | ARG185 | |
| B | GLN202 | |
| B | TYR210 | |
| B | GLN216 | |
| B | GLU499 | |
| B | ASN510 | |
| B | TYR514 | |
| A | ARG185 | |
| B | TYR560 | |
| B | ARG563 | |
| B | ASN572 | |
| A | GLN202 | |
| A | TYR210 | |
| A | GLN216 | |
| A | GLU499 | |
| A | ASN510 | |
| A | TYR514 | |
| A | TYR560 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30872481, ECO:0007744|PDB:6I02 |
| Chain | Residue | Details |
| A | GLN213 | |
| B | GLN213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30872481, ECO:0007744|PDB:6HZZ, ECO:0007744|PDB:6I01, ECO:0007744|PDB:6I02 |
| Chain | Residue | Details |
| A | THR238 | |
| B | ASP392 | |
| A | GLU240 | |
| A | THR268 | |
| A | ASN269 | |
| A | ASP392 | |
| B | THR238 | |
| B | GLU240 | |
| B | THR268 | |
| B | ASN269 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:F1QR43 |
| Chain | Residue | Details |
| A | LYS429 | |
| B | LYS429 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Critical for catalysis => ECO:0000250|UniProtKB:F1QR43 |
| Chain | Residue | Details |
| A | TYR180 | |
| A | ARG187 | |
| A | TYR560 | |
| B | TYR180 | |
| B | ARG187 | |
| B | TYR560 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Critical for catalysis => ECO:0000269|PubMed:30872481 |
| Chain | Residue | Details |
| A | PHE578 | |
| B | PHE578 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:30872481, ECO:0007744|PDB:6HZZ, ECO:0007744|PDB:6I01, ECO:0007744|PDB:6I02 |
| Chain | Residue | Details |
| A | ASN225 | |
| B | ASN225 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30872481, ECO:0007744|PDB:6HZZ, ECO:0007744|PDB:6I01, ECO:0007744|PDB:6I02 |
| Chain | Residue | Details |
| A | ASN303 | |
| A | ASN393 | |
| B | ASN303 | |
| B | ASN393 |
