6HZZ

Structure of human D-glucuronyl C5 epimerase

Summary for 6HZZ

Entry DOI	10.2210/pdb6hzz/pdb
Descriptor	D-glucuronyl C5-epimerase, CHLORIDE ION, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	c5-epimerase, heparan sulfate, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	124809.45
Authors	Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Le Narvor, C.,Goulet, A.,Fadel, F.,Vives, R.R.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y. (deposition date: 2018-10-24, release date: 2019-04-03, Last modification date: 2024-01-24)
Primary citation	Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Delauzun, V.,Le Narvor, C.,Richard, E.,Henault, J.,Goulet, A.,Fadel, F.,Vives, R.R.,Priem, B.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y. Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Proc.Natl.Acad.Sci.USA, 116:6760-6765, 2019 Cited by PubMed: 30872481 DOI: 10.1073/pnas.1818333116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation