6HZZ
Structure of human D-glucuronyl C5 epimerase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | D-glucuronyl C5-epimerase | polymer | 527 | 60310.4 | 2 | UniProt (O94923) Pfam (PF21174) Pfam (PF06662) In PDB | Homo sapiens (Human) | Heparan sulfate C5-epimerase,Hsepi,Heparin/heparan sulfate:glucuronic acid C5-epimerase,Heparosan-N-sulfate-glucuronate 5-epimerase |
2 | C | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
3 | D, G | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
4 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
6 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
7 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
8 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
9 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
10 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
11 | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
A, B: 98 - 617 (UniProt: O94923)
PDB | External Database | Details |
---|---|---|
Asp 91 | - | expression tag |
Tyr 92 | - | expression tag |
Lys 93 | - | expression tag |
Asp 94 | - | expression tag |
Asp 95 | - | expression tag |
Asp 96 | - | expression tag |
Asp 97 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120620.7 | |
Branched | Number of molecules | 5 |
Total formula weight | 3565.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 623.4 | |
All* | Total formula weight | 124809.5 |