6DGQ

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10506

Summary for 6DGQ

Entry DOI	10.2210/pdb6dgq/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide (3 entities in total)
Functional Keywords	nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	63467.77
Authors	Shang, J.,Kojetin, D.J. (deposition date: 2018-05-17, release date: 2019-05-22, Last modification date: 2023-10-11)
Primary citation	Shang, J.,Brust, R.,Griffin, P.R.,Kamenecka, T.M.,Kojetin, D.J. Quantitative structural assessment of graded receptor agonism. Proc.Natl.Acad.Sci.USA, 116:22179-22188, 2019 Cited by PubMed: 31611383 DOI: 10.1073/pnas.1909016116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation