6DGQ

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10506

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005829cellular_componentcytosol
A0043231cellular_componentintracellular membrane-bounded organelle
A0000790cellular_componentnuclear chromatin
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0032991cellular_componentprotein-containing complex
A0090575cellular_componentRNA polymerase II transcription factor complex
A0033613molecular_functionactivating transcription factor binding
A0051393molecular_functionalpha-actinin binding
A0050544molecular_functionarachidonic acid binding
A0003682molecular_functionchromatin binding
A0050692molecular_functionDBD domain binding
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
A0003690molecular_functiondouble-stranded DNA binding
A0008144molecular_functiondrug binding
A0070888molecular_functionE-box binding
A0019899molecular_functionenzyme binding
A0030331molecular_functionestrogen receptor binding
A0005504molecular_functionfatty acid binding
A0042802molecular_functionidentical protein binding
A0050693molecular_functionLBD domain binding
A0008289molecular_functionlipid binding
A0004879molecular_functionnuclear receptor activity
A0030374molecular_functionnuclear receptor transcription coactivator activity
A0042277molecular_functionpeptide binding
A0004955molecular_functionprostaglandin receptor activity
A0008022molecular_functionprotein C-terminus binding
A0046982molecular_functionprotein heterodimerization activity
A0019903molecular_functionprotein phosphatase binding
A0043621molecular_functionprotein self-association
A0046965molecular_functionretinoid X receptor binding
A0000977molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding
A0001103molecular_functionRNA polymerase II repressing transcription factor binding
A0038023molecular_functionsignaling receptor activity
A0003707molecular_functionsteroid hormone receptor activity
A0008134molecular_functiontranscription factor binding
A0044212molecular_functiontranscription regulatory region DNA binding
A0000976molecular_functiontranscription regulatory region sequence-specific DNA binding
A0008270molecular_functionzinc ion binding
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0031100biological_processanimal organ regeneration
A0030154biological_processcell differentiation
A0045165biological_processcell fate commitment
A0048469biological_processcell maturation
A0071455biological_processcellular response to hyperoxia
A0032869biological_processcellular response to insulin stimulus
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071300biological_processcellular response to retinoic acid
A0071306biological_processcellular response to vitamin E
A0030855biological_processepithelial cell differentiation
A0006631biological_processfatty acid metabolic process
A0019395biological_processfatty acid oxidation
A0042593biological_processglucose homeostasis
A0007507biological_processheart development
A0009755biological_processhormone-mediated signaling pathway
A0045087biological_processinnate immune response
A0055088biological_processlipid homeostasis
A0006629biological_processlipid metabolic process
A0042953biological_processlipoprotein transport
A0015909biological_processlong-chain fatty acid transport
A0045713biological_processlow-density lipoprotein particle receptor biosynthetic process
A0010742biological_processmacrophage derived foam cell differentiation
A0030224biological_processmonocyte differentiation
A0007275biological_processmulticellular organism development
A0002674biological_processnegative regulation of acute inflammatory response
A0016525biological_processnegative regulation of angiogenesis
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0030308biological_processnegative regulation of cell growth
A0010887biological_processnegative regulation of cholesterol storage
A0032966biological_processnegative regulation of collagen biosynthetic process
A0060965biological_processnegative regulation of gene silencing by miRNA
A0060336biological_processnegative regulation of interferon-gamma-mediated signaling pathway
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A2000230biological_processnegative regulation of pancreatic stellate cell proliferation
A0010871biological_processnegative regulation of receptor biosynthetic process
A0010891biological_processnegative regulation of sequestering of triglyceride
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0051974biological_processnegative regulation of telomerase activity
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0045892biological_processnegative regulation of transcription, DNA-templated
A1905563biological_processnegative regulation of vascular endothelial cell proliferation
A1904706biological_processnegative regulation of vascular smooth muscle cell proliferation
A0035357biological_processperoxisome proliferator activated receptor signaling pathway
A0001890biological_processplacenta development
A0043388biological_processpositive regulation of DNA binding
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0045600biological_processpositive regulation of fat cell differentiation
A0046321biological_processpositive regulation of fatty acid oxidation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0060100biological_processpositive regulation of phagocytosis, engulfment
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045893biological_processpositive regulation of transcription, DNA-templated
A1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
A0061614biological_processpri-miRNA transcription by RNA polymerase II
A0008217biological_processregulation of blood pressure
A0060694biological_processregulation of cholesterol transporter activity
A0042752biological_processregulation of circadian rhythm
A0019216biological_processregulation of lipid metabolic process
A0006357biological_processregulation of transcription by RNA polymerase II
A0060850biological_processregulation of transcription involved in cell fate commitment
A0031000biological_processresponse to caffeine
A0009409biological_processresponse to cold
A0043627biological_processresponse to estrogen
A0035902biological_processresponse to immobilization stress
A0033993biological_processresponse to lipid
A0009612biological_processresponse to mechanical stimulus
A1901558biological_processresponse to metformin
A0007584biological_processresponse to nutrient
A0032526biological_processresponse to retinoic acid
A0042594biological_processresponse to starvation
A0033189biological_processresponse to vitamin A
A0048511biological_processrhythmic process
A0007165biological_processsignal transduction
A0006367biological_processtranscription initiation from RNA polymerase II promoter
A0050872biological_processwhite fat cell differentiation
B0005829cellular_componentcytosol
B0043231cellular_componentintracellular membrane-bounded organelle
B0000790cellular_componentnuclear chromatin
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0048471cellular_componentperinuclear region of cytoplasm
B0032991cellular_componentprotein-containing complex
B0090575cellular_componentRNA polymerase II transcription factor complex
B0033613molecular_functionactivating transcription factor binding
B0051393molecular_functionalpha-actinin binding
B0050544molecular_functionarachidonic acid binding
B0003682molecular_functionchromatin binding
B0050692molecular_functionDBD domain binding
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
B0003690molecular_functiondouble-stranded DNA binding
B0008144molecular_functiondrug binding
B0070888molecular_functionE-box binding
B0019899molecular_functionenzyme binding
B0030331molecular_functionestrogen receptor binding
B0005504molecular_functionfatty acid binding
B0042802molecular_functionidentical protein binding
B0050693molecular_functionLBD domain binding
B0008289molecular_functionlipid binding
B0004879molecular_functionnuclear receptor activity
B0030374molecular_functionnuclear receptor transcription coactivator activity
B0042277molecular_functionpeptide binding
B0004955molecular_functionprostaglandin receptor activity
B0008022molecular_functionprotein C-terminus binding
B0046982molecular_functionprotein heterodimerization activity
B0019903molecular_functionprotein phosphatase binding
B0043621molecular_functionprotein self-association
B0046965molecular_functionretinoid X receptor binding
B0000977molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding
B0001103molecular_functionRNA polymerase II repressing transcription factor binding
B0038023molecular_functionsignaling receptor activity
B0003707molecular_functionsteroid hormone receptor activity
B0008134molecular_functiontranscription factor binding
B0044212molecular_functiontranscription regulatory region DNA binding
B0000976molecular_functiontranscription regulatory region sequence-specific DNA binding
B0008270molecular_functionzinc ion binding
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0031100biological_processanimal organ regeneration
B0030154biological_processcell differentiation
B0045165biological_processcell fate commitment
B0048469biological_processcell maturation
B0071455biological_processcellular response to hyperoxia
B0032869biological_processcellular response to insulin stimulus
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0071380biological_processcellular response to prostaglandin E stimulus
B0071300biological_processcellular response to retinoic acid
B0071306biological_processcellular response to vitamin E
B0030855biological_processepithelial cell differentiation
B0006631biological_processfatty acid metabolic process
B0019395biological_processfatty acid oxidation
B0042593biological_processglucose homeostasis
B0007507biological_processheart development
B0009755biological_processhormone-mediated signaling pathway
B0045087biological_processinnate immune response
B0055088biological_processlipid homeostasis
B0006629biological_processlipid metabolic process
B0042953biological_processlipoprotein transport
B0015909biological_processlong-chain fatty acid transport
B0045713biological_processlow-density lipoprotein particle receptor biosynthetic process
B0010742biological_processmacrophage derived foam cell differentiation
B0030224biological_processmonocyte differentiation
B0007275biological_processmulticellular organism development
B0002674biological_processnegative regulation of acute inflammatory response
B0016525biological_processnegative regulation of angiogenesis
B0043537biological_processnegative regulation of blood vessel endothelial cell migration
B0030308biological_processnegative regulation of cell growth
B0010887biological_processnegative regulation of cholesterol storage
B0032966biological_processnegative regulation of collagen biosynthetic process
B0060965biological_processnegative regulation of gene silencing by miRNA
B0060336biological_processnegative regulation of interferon-gamma-mediated signaling pathway
B0010745biological_processnegative regulation of macrophage derived foam cell differentiation
B2000230biological_processnegative regulation of pancreatic stellate cell proliferation
B0010871biological_processnegative regulation of receptor biosynthetic process
B0010891biological_processnegative regulation of sequestering of triglyceride
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0051974biological_processnegative regulation of telomerase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0045892biological_processnegative regulation of transcription, DNA-templated
B1905563biological_processnegative regulation of vascular endothelial cell proliferation
B1904706biological_processnegative regulation of vascular smooth muscle cell proliferation
B0035357biological_processperoxisome proliferator activated receptor signaling pathway
B0001890biological_processplacenta development
B0043388biological_processpositive regulation of DNA binding
B0051091biological_processpositive regulation of DNA-binding transcription factor activity
B0045600biological_processpositive regulation of fat cell differentiation
B0046321biological_processpositive regulation of fatty acid oxidation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0060100biological_processpositive regulation of phagocytosis, engulfment
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0045893biological_processpositive regulation of transcription, DNA-templated
B1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
B0061614biological_processpri-miRNA transcription by RNA polymerase II
B0008217biological_processregulation of blood pressure
B0060694biological_processregulation of cholesterol transporter activity
B0042752biological_processregulation of circadian rhythm
B0019216biological_processregulation of lipid metabolic process
B0006357biological_processregulation of transcription by RNA polymerase II
B0060850biological_processregulation of transcription involved in cell fate commitment
B0031000biological_processresponse to caffeine
B0009409biological_processresponse to cold
B0043627biological_processresponse to estrogen
B0035902biological_processresponse to immobilization stress
B0033993biological_processresponse to lipid
B0009612biological_processresponse to mechanical stimulus
B1901558biological_processresponse to metformin
B0007584biological_processresponse to nutrient
B0032526biological_processresponse to retinoic acid
B0042594biological_processresponse to starvation
B0033189biological_processresponse to vitamin A
B0048511biological_processrhythmic process
B0007165biological_processsignal transduction
B0006367biological_processtranscription initiation from RNA polymerase II promoter
B0050872biological_processwhite fat cell differentiation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC113binding site for residue GBV A 501
ChainResidue
APHE282
AGLY284
ACYS285
ASER289
AHIS323
ALEU330
AILE341
AMET364
AHIS449
ALEU453
ALEU469
ATYR473
AHOH671

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GBV_6dgq_A_50126N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide binding site
ChainResidueligand
AILE249GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ALEU255GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AARG280-PHE282GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AGLY284-GLN286GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AARG288-SER289GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AHIS323GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AILE326-TYR327GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ALEU330GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AVAL339-SER342GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AMET348GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
APHE363-MET364GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ALYS367GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
AHIS449GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ALEU453GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ALEU469GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide
ATYR473GBV: N-(2-{4-[(2,4-dioxo-3,4-dihydro-2H-1lambda~4~,3-thiazol-5-yl)methyl]phenoxy}ethyl)-5-[(3R)-1,2-dithiolan-3-yl]pentanamide

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails