6BKJ
Crystal Structure of Human Calpain-3 Protease Core in Complex with Leupeptin
Summary for 6BKJ
Entry DOI | 10.2210/pdb6bkj/pdb |
Related | 6BJD |
Related PRD ID | PRD_000216 |
Descriptor | Calpain-3, Leupeptin, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | calcium binding, cysteine protease, calpain, p94, inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 179863.64 |
Authors | Ye, Q.,Campbell, R.L.,Davies, P.L. (deposition date: 2017-11-08, release date: 2018-02-07, Last modification date: 2023-10-04) |
Primary citation | Ye, Q.,Campbell, R.L.,Davies, P.L. Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation. J. Biol. Chem., 293:4056-4070, 2018 Cited by PubMed: 29382717DOI: 10.1074/jbc.RA117.001097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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