6BKJ
Crystal Structure of Human Calpain-3 Protease Core in Complex with Leupeptin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Calpain-3 | polymer | 382 | 44456.2 | 4 | UniProt (P20807) Pfam (PF00648) | Homo sapiens (Human) | Calcium-activated neutral proteinase 3,CANP 3,Calpain L3,Calpain p94,Muscle-specific calcium-activated neutral protease 3,New calpain 1,nCL-1 |
| 2 | E, F, G, H (F, G, H, I) | Leupeptin | polymer | 4 | 429.6 | 4 | BIRD (PRD_000216) | Streptomyces roseus | |
| 3 | I, J, K, L, M... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | Q, R, S, T, U (A, B, C, D, H) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 46 - 419 (UniProt: P20807)
| PDB | External Database | Details |
|---|---|---|
| Leu 420 | - | expression tag |
| Glu 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 179543.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 320.6 | |
| All* | Total formula weight | 179863.6 |
