Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 501 |
| Chain | Residue |
| A | ILE113 |
| A | ASP114 |
| A | GLY115 |
| A | ASN117 |
| A | ASP120 |
| A | GLU199 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | ASP394 |
| A | GLU396 |
| A | GLU364 |
| A | ASP371 |
| A | THR392 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 501 |
| Chain | Residue |
| B | ILE113 |
| B | ASP114 |
| B | GLY115 |
| B | ASN117 |
| B | ASP120 |
| B | GLU199 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| B | GLU364 |
| B | ASP371 |
| B | THR392 |
| B | ASP394 |
| B | GLU396 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 501 |
| Chain | Residue |
| C | ILE113 |
| C | ASP114 |
| C | GLY115 |
| C | ASN117 |
| C | ASP120 |
| C | GLU199 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 502 |
| Chain | Residue |
| C | GLU364 |
| C | ASP371 |
| C | THR392 |
| C | ASP394 |
| C | GLU396 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 501 |
| Chain | Residue |
| D | ILE113 |
| D | GLY115 |
| D | ASN117 |
| D | ASP120 |
| D | GLU199 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 502 |
| Chain | Residue |
| D | GLU364 |
| D | ASP371 |
| D | THR392 |
| D | ASP394 |
| D | GLU396 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for Di-peptide ACE F 355 and LEU F 356 |
| Chain | Residue |
| A | GLY221 |
| F | LEU357 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide LEU F 357 and AR7 F 358 |
| Chain | Residue |
| A | GLY127 |
| A | CYS129 |
| A | TRP130 |
| A | LYS220 |
| A | GLY221 |
| A | GLY222 |
| F | ACE355 |
| F | LEU356 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide ACE G 355 and LEU G 356 |
| Chain | Residue |
| B | GLY222 |
| D | TYR170 |
| G | LEU357 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LEU G 357 and AR7 G 358 |
| Chain | Residue |
| B | GLY127 |
| B | CYS129 |
| B | TRP130 |
| B | GLY221 |
| B | GLY222 |
| B | GLY333 |
| B | HIS334 |
| B | ALA335 |
| G | ACE355 |
| G | LEU356 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for Di-peptide ACE H 355 and LEU H 356 |
| Chain | Residue |
| H | LEU357 |
| H | AR7358 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide LEU H 357 and AR7 H 358 |
| Chain | Residue |
| C | CYS129 |
| C | TRP130 |
| C | GLY221 |
| C | GLY222 |
| C | GLY333 |
| C | HIS334 |
| H | ACE355 |
| H | LEU356 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for Di-peptide ACE I 355 and LEU I 356 |
| Chain | Residue |
| B | TYR170 |
| I | LEU357 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide LEU I 357 and AR7 I 358 |
| Chain | Residue |
| D | GLN123 |
| D | GLY127 |
| D | CYS129 |
| D | GLY221 |
| D | GLY222 |
| D | GLY333 |
| D | HIS334 |
| I | LEU356 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide AR7 I 358 and CYS D 129 |
| Chain | Residue |
| D | VAL363 |
| D | GLY395 |
| I | LEU357 |
| D | GLN123 |
| D | GLY127 |
| D | ASP128 |
| D | TRP130 |
| D | PHE131 |
| D | LEU132 |
| D | ALA133 |
| D | GLY333 |
| D | HIS334 |
| D | ARG357 |
| D | PRO359 |
| D | TRP360 |
| D | GLY361 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGeLGDCWFlAA |
| Chain | Residue | Details |
| A | GLN123-ALA134 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]} |
