5VBR

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH Volasertib

Summary for 5VBR

Entry DOI	10.2210/pdb5vbr/pdb
Related	5VBO 5VBP 5VBQ
Descriptor	Bromodomain testis-specific protein, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28630.01
Authors	EMBER, S.W.,ZHU, J.-Y.,SCHONBRUNN, E. (deposition date: 2017-03-30, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citation	Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021 Cited by PubMed: 34710325 DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation