5VBQ

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH BI2536

Summary for 5VBQ

Entry DOI	10.2210/pdb5vbq/pdb
Related	5VBO 5VBP 5VBR
Descriptor	Bromodomain testis-specific protein, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28710.58
Authors	EMBER, S.W.,ZHU, J.-Y.,SCHONBRUNN, E. (deposition date: 2017-03-30, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citation	Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021 Cited by PubMed: 34710325 DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation