5VBQ

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH BI2536

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue R78 A 201

Chain	Residue
A	PRO51
A	HOH351
A	LEU61
A	LEU63
A	ASN109
A	EDO208
A	HOH304
A	HOH319
A	HOH331
A	HOH343

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 202

Chain	Residue
A	ASN77

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 203

Chain	Residue
A	ILE69
A	ILE70
A	LYS71
A	ASN72
A	ASN104
A	EDO204
A	HOH313

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 204

Chain	Residue
A	SER103
A	ASN104
A	EDO203
A	HOH329
A	HOH359
B	TYR106
B	GLN120

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 205

Chain	Residue
A	VAL56
A	ASP57
A	ALA58
A	VAL59
A	TYR67
A	HOH347

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 206

Chain	Residue
A	PRO55
A	ASN77
A	THR78

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 207

Chain	Residue
A	PHE48
A	LYS71
A	ASP114
A	LEU117
A	HOH309
A	HOH360

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 208

Chain	Residue
A	PRO51
A	PRO55
A	ASP57
A	LEU61
A	R78201
A	HOH310
A	HOH321

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 209

Chain	Residue
A	ARG82

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 210

Chain	Residue
A	ASN72
A	ARG82
A	ASP97
A	HOH307

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 211

Chain	Residue
A	LYS41
A	LYS80
A	HOH345

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 212

Chain	Residue
A	THR29
A	LYS86
A	HOH334
A	HOH366

---

site_id	AD4
Number of Residues	10
Details	binding site for residue R78 B 201

Chain	Residue
B	PRO51
B	LEU61
B	LEU63
B	ASN109
B	EDO204
B	HOH308
B	HOH311
B	HOH312
B	HOH332
B	HOH336

---

site_id	AD5
Number of Residues	7
Details	binding site for residue EDO B 202

Chain	Residue
B	ILE69
B	ILE70
B	LYS71
B	ASN72
B	ASN104
B	EDO205
B	HOH302

---

site_id	AD6
Number of Residues	6
Details	binding site for residue EDO B 203

Chain	Residue
B	VAL56
B	ASP57
B	ALA58
B	VAL59
B	TYR67
B	HOH323

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO B 204

Chain	Residue
B	PRO51
B	PRO55
B	ASP57
B	R78201
B	HOH306
B	HOH325

---

site_id	AD8
Number of Residues	7
Details	binding site for residue EDO B 205

Chain	Residue
A	TYR106
A	GLN120
A	HOH306
B	SER103
B	ASN104
B	EDO202
B	HOH335

---

site_id	AD9
Number of Residues	2
Details	binding site for residue EDO B 206

Chain	Residue
B	GLN36
B	LYS80

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO B 207

Chain	Residue
B	HOH333
B	HOH334
B	LYS71
B	PRO73

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SwpFqrpvDavklqlpDYYtiIknpMdlntIkkrlenky..Yakaseciedfnt.MfsNCylY

Chain	Residue	Details
A	SER49-TYR108

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22901802","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FLP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Histone H4K5ac binding","evidences":[{"source":"UniProtKB","id":"Q91Y44","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---