5VBR
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH Volasertib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain testis-specific protein | polymer | 113 | 13319.4 | 2 | UniProt (Q58F21) Pfam (PF00439) | Homo sapiens (Human) | Cancer/testis antigen 9,CT9,RING3-like protein |
| 2 | C, K (A, B) | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide | non-polymer | 618.8 | 2 | Chemie (IBI) | |||
| 3 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 4 | J, Q (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | R, S (A, B) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 137 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Ser 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26638.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1991.3 | |
| All* | Total formula weight | 28630.0 |
