5VBP
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH RO3280
Summary for 5VBP
Entry DOI | 10.2210/pdb5vbp/pdb |
Related | 5VBO 5VBQ 5VBR |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
Functional Keywords | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, inhibitor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31718.50 |
Authors | EMBER, S.W.,ZHU, J.-Y.,SCHONBRUNN, E. (deposition date: 2017-03-30, release date: 2018-04-04, Last modification date: 2023-10-04) |
Primary citation | Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021 Cited by PubMed: 34710325DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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