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5M6Y

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline Fasudil-derivative

5M6Y の概要
エントリーDOI10.2210/pdb5m6y/pdb
関連するPDBエントリー5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V
分子名称cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline, ... (5 entities in total)
機能のキーワードpka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase
由来する生物種Cricetulus griseus (Chinese hamster)
詳細
タンパク質・核酸の鎖数2
化学式量合計43763.75
構造登録者
Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2016-10-26, 公開日: 2018-06-06, 最終更新日: 2024-11-06)
主引用文献Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with differently methylated Fasudil-derived ligands
To be Published,
実験手法
X-RAY DIFFRACTION (1.367 Å)
構造検証レポート
Validation report summary of 5m6y
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-12-18に公開中

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