5M0L
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (Ligand 02)
Summary for 5M0L
Entry DOI | 10.2210/pdb5m0l/pdb |
Related | 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-methylisoquinoline-5-sulfonamide, ... (5 entities in total) |
Functional Keywords | pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase, ligand 02 |
Biological source | Cricetulus griseus (Chinese hamster) More |
Total number of polymer chains | 2 |
Total formula weight | 43902.88 |
Authors | Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-05, release date: 2018-06-06, Last modification date: 2024-01-17) |
Primary citation | Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G. Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.465 Å) |
Structure validation
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