5LPO
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one
Summary for 5LPO
Entry DOI | 10.2210/pdb5lpo/pdb |
Related | 1P0D 4KWO 4LEQ 4PUK 5I00 5I02 5I06 |
Descriptor | Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ... (7 entities in total) |
Functional Keywords | carbohydrate-based inhibitors, homodimer, shigellosis, transferase, transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) |
Total number of polymer chains | 1 |
Total formula weight | 44270.45 |
Authors | Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-08-14, release date: 2017-08-30, Last modification date: 2024-01-10) |
Primary citation | Ehrmann, F.R.,Botzanowski, T.,Pfaffender, T.,Heine, A.,Diederich, F.,Sanglier-Cianferani, S.,Klebe, G. Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer To be published, |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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