5I00

tRNA guanine transglycosylase (TGT) in co-crystallized complex with 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 5I00

• Entry DOI: 10.2210/pdb5i00/pdb
• Related: 1Y5V 1Y5W 1Y5X 3EOS 3GE7 4FR6 4FSA 4KWO 4LEQ 4PUK
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (7 entities in total)
• Functional Keywords: co-crystalization, shigellosis, transferase, transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• Total number of polymer chains: 1
• Total formula weight: 43725.37

Authors

Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-02-03, release date: 2017-02-15, Last modification date: 2024-01-10)

• Primary citation: Ehrmann, F.R.,Stojko, J.,Reuter, K.,Heine, A.,Klebe, G.,Sanglier-Cianferani, S.,Diederich, F.; Co-crystallization, Isothermal titration calorimetry and nanoESI-MS reveal dimer disturbing inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (1.49 Å)