5LPO
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Queuine tRNA-ribosyltransferase | polymer | 388 | 43069.8 | 1 | UniProt (P28720) Pfam (PF01702) | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) | Guanine insertion enzyme,tRNA-guanine transglycosylase |
| 2 | B, C, D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 3 | G (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | H (A) | 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one | non-polymer | 418.4 | 1 | Chemie (725) | |||
| 5 | I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | J (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 7 | K (A) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 1 - 386 (UniProt: P28720)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Lys 312 | Thr 312 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43069.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1200.6 | |
| All* | Total formula weight | 44270.4 |
