5KA2
Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant, open state
Summary for 5KA2
Entry DOI | 10.2210/pdb5ka2/pdb |
Related | 5K9V 5K9W 5KA0 5KA1 5KA3 5KA4 5KA7 5KA8 5KA9 5KAA 5KAB |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | protein tyrosine phosphatase, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35879.36 |
Authors | Choy, M.S.,Peti, W.,Page, R. (deposition date: 2016-06-01, release date: 2017-03-08, Last modification date: 2024-02-28) |
Primary citation | Choy, M.S.,Li, Y.,Machado, L.E.,Kunze, M.B.,Connors, C.R.,Wei, X.,Lindorff-Larsen, K.,Page, R.,Peti, W. Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65:644-658.e5, 2017 Cited by PubMed: 28212750DOI: 10.1016/j.molcel.2017.01.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.071 Å) |
Structure validation
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