5KA4

Protein Tyrosine Phosphatase 1B T178A mutant, open state

Summary for 5KA4

Entry DOI	10.2210/pdb5ka4/pdb
Related	5K9V 5K9W 5KA0 5KA1 5KA2 5KA3 5KA7 5KA8 5KA9 5KAA 5KAB 5KAC 5KAD
Descriptor	Tyrosine-protein phosphatase non-receptor type 1 (2 entities in total)
Functional Keywords	protein tyrosine phosphatase, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	35514.48
Authors	Choy, M.S.,Peti, W.,Page, R. (deposition date: 2016-06-01, release date: 2017-03-08, Last modification date: 2024-02-28)
Primary citation	Choy, M.S.,Li, Y.,Machado, L.E.,Kunze, M.B.,Connors, C.R.,Wei, X.,Lindorff-Larsen, K.,Page, R.,Peti, W. Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65:644-658.e5, 2017 Cited by PubMed: 28212750 DOI: 10.1016/j.molcel.2017.01.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.185 Å)

Structure validation