5FP7

Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid

5FP7 の概要

• エントリーDOI: 10.2210/pdb5fp7/pdb
• 関連するPDBエントリー: 5FP3 5FP4 5FP8 5FP9 5FPA 5FPB
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, FE (II) ION, ... (7 entities in total)
• 機能のキーワード: inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39888.92

構造登録者

Chung, C. (登録日: 2015-11-27, 公開日: 2016-11-09, 最終更新日: 2024-05-08)

• 主引用文献: Westaway, S.M.,Preston, A.G.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.W.,Drewes, G.,Eagle, R.,Garton, N.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Pemberton, M.,Rioja, I.,Seal, G.A.,Shipley, T.,Singh, O.,Suckling, C.J.,Taylor, J.,Thomas, P.,Wilson, D.M.,Lee, K.,Prinjha, R.K.; Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.; J. Med. Chem., 59:1370-1387, 2016; PubMed: 26771203; DOI: 10.1021/acs.jmedchem.5b01538

実験手法

X-RAY DIFFRACTION (2 Å)