5E23

Human transthyretin (TTR) complexed with (2,7-Dibromo-fluoren-9-ylideneaminooxy)-acetic acid

Summary for 5E23

• Entry DOI: 10.2210/pdb5e23/pdb
• Related: 4TQ8 4TQH 4TQI 4TQP
• Descriptor: Transthyretin, {[(2,7-dibromo-9H-fluoren-9-ylidene)amino]oxy}acetic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: human transthyretin (ttr), fibril formation inhibitors, fluorenyl based inhibitor, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28043.90

Authors

Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2015-09-30, release date: 2016-03-23, Last modification date: 2024-01-10)

• Primary citation: Ciccone, L.,Nencetti, S.,Rossello, A.,Stura, E.A.,Orlandini, E.; Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR).; J Enzyme Inhib Med Chem, 31:40-51, 2016; PubMed: 27067161; DOI: 10.3109/14756366.2016.1167048

Experimental method

X-RAY DIFFRACTION (1.41 Å)