4RWO
Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position
Summary for 4RWO
Entry DOI | 10.2210/pdb4rwo/pdb |
Related | 4RWN 4RWP 4RWQ |
Descriptor | RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), 2'-5'-oligoadenylate synthase 1, ... (6 entities in total) |
Functional Keywords | innate immunity, interferon-induced, transferase-rna complex, transferase/rna |
Biological source | Sus scrofa (pigs,swine,wild boar) More |
Cellular location | Cytoplasm : Q29599 |
Total number of polymer chains | 3 |
Total formula weight | 53963.44 |
Authors | Lohoefener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R. (deposition date: 2014-12-05, release date: 2015-05-20, Last modification date: 2024-02-28) |
Primary citation | Lohofener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R. The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23:851-862, 2015 Cited by PubMed: 25892109DOI: 10.1016/j.str.2015.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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