4QMZ

MST3 IN COMPLEX WITH SUNITINIB

4QMZ の概要

• エントリーDOI: 10.2210/pdb4qmz/pdb
• 関連するPDBエントリー: 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMV 4QMW 4QMX 4QMY 4QMZ
• 分子名称: SERINE/THREONINE-PROTEIN KINASE 24, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9Y6E0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35493.31

構造登録者

Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (登録日: 2014-06-16, 公開日: 2015-07-01, 最終更新日: 2023-09-20)

• 主引用文献: Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E.; Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).; Chemmedchem, 11:1137-1144, 2016; PubMed: 27135311; DOI: 10.1002/cmdc.201600115

実験手法

X-RAY DIFFRACTION (1.88 Å)