4QMZ

MST3 IN COMPLEX WITH SUNITINIB

Summary for 4QMZ

Entry DOI	10.2210/pdb4qmz/pdb
Related	4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMV 4QMW 4QMX 4QMY 4QMZ
Descriptor	SERINE/THREONINE-PROTEIN KINASE 24, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y6E0
Total number of polymer chains	1
Total formula weight	35493.31
Authors	Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2023-09-20)
Primary citation	Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E. Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3). Chemmedchem, 11:1137-1144, 2016 Cited by PubMed: 27135311 DOI: 10.1002/cmdc.201600115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation