4QMW

MST3 IN COMPLEX WITH PP-121, 1-CYCLOPENTYL-3-(1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

Summary for 4QMW

• Entry DOI: 10.2210/pdb4qmw/pdb
• Related: 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMV 4QMX 4QMY 4QMZ 4QO9
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 24, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y6E0
• Total number of polymer chains: 1
• Total formula weight: 35464.41

Authors

Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2023-09-20)

• Primary citation: Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E.; Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).; Chemmedchem, 11:1137-1144, 2016; PubMed: 27135311; DOI: 10.1002/cmdc.201600115

Experimental method

X-RAY DIFFRACTION (1.6 Å)