4QMX

MST3 in complex with SARACATINIB

Summary for 4QMX

Entry DOI	10.2210/pdb4qmx/pdb
Related	4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMR 4QMS 4QMT 4QMV 4QMW 4QMX 4QMZ
Descriptor	SERINE/THREONINE-PROTEIN KINASE 24, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE (3 entities in total)
Functional Keywords	protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y6E0
Total number of polymer chains	1
Total formula weight	35565.96
Authors	Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2023-09-20)
Primary citation	Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E. Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3). Chemmedchem, 11:1137-1144, 2016 Cited by PubMed: 27135311 DOI: 10.1002/cmdc.201600115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.882 Å)

Structure validation