4QML

MST3 in complex with AMP-PNP

Summary for 4QML

Related4QMM 4QMN 4QMO 4QMP 4QMQ 4QMR 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ
DescriptorSerine/threonine-protein kinase 24, ethane-1,2-diol, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsprotein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9Y6E0
Total number of polymer chains1
Total molecular weight35616.5
Authors
Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2018-04-11)
Primary citation
Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E.
Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).
Chemmedchem, 11:1137-1144, 2016
PubMed: 27135311 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201600115
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.882 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23040.4%0.8%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload