4QMP
MST3 IN COMPLEX WITH CDK1/2 INHIBITOR III, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Summary for 4QMP
Entry DOI | 10.2210/pdb4qmp/pdb |
Related | 4QML 4QMM 4QMN 4QMO 4QMQ 4QMR 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ |
Descriptor | Serine/threonine-protein kinase 24, 1,2-ETHANEDIOL, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, ... (4 entities in total) |
Functional Keywords | protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y6E0 |
Total number of polymer chains | 1 |
Total formula weight | 35511.44 |
Authors | Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2023-09-20) |
Primary citation | Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E. Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3). Chemmedchem, 11:1137-1144, 2016 Cited by PubMed: 27135311DOI: 10.1002/cmdc.201600115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report