4PNK

G protein-coupled receptor kinase 2 in complex with GSK180736A

Summary for 4PNK

• Entry DOI: 10.2210/pdb4pnk/pdb
• Related: 3V5W 4MK0 4PNI
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: protein kinase, hydrolase, atp binding, phosphorylation, peripheral membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 125320.01

Authors

Homan, K.T.,Larimore, K.M.,Elkins, J.,Knapp, S.,Tesmer, J.J.G. (deposition date: 2014-05-23, release date: 2014-10-08, Last modification date: 2023-12-27)

• Primary citation: Homan, K.T.,Larimore, K.M.,Elkins, J.M.,Szklarz, M.,Knapp, S.,Tesmer, J.J.; Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.; Acs Chem.Biol., 10:310-319, 2015; PubMed: 25238254; DOI: 10.1021/cb5006323

Experimental method

X-RAY DIFFRACTION (2.56 Å)