4PNK

G protein-coupled receptor kinase 2 in complex with GSK180736A

4PNK の概要

• エントリーDOI: 10.2210/pdb4pnk/pdb
• 関連するPDBエントリー: 3V5W 4MK0 4PNI
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• 機能のキーワード: protein kinase, hydrolase, atp binding, phosphorylation, peripheral membrane protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 125320.01

構造登録者

Homan, K.T.,Larimore, K.M.,Elkins, J.,Knapp, S.,Tesmer, J.J.G. (登録日: 2014-05-23, 公開日: 2014-10-08, 最終更新日: 2023-12-27)

• 主引用文献: Homan, K.T.,Larimore, K.M.,Elkins, J.M.,Szklarz, M.,Knapp, S.,Tesmer, J.J.; Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.; Acs Chem.Biol., 10:310-319, 2015; PubMed: 25238254; DOI: 10.1021/cb5006323

実験手法

X-RAY DIFFRACTION (2.56 Å)