4OYT

Crystal structure of ternary complex of Plasmodium vivax SHMT with D-serine and folinic acid

Summary for 4OYT

Entry DOI	10.2210/pdb4oyt/pdb
Related	4O6Z 4PFF 4PFN
Descriptor	Serine hydroxymethyltransferase, putative, (2R)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-oxidanyl-propanoic acid, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... (7 entities in total)
Functional Keywords	alpha and beta protein, transferase, methyltransferase activity
Biological source	Plasmodium vivax
Total number of polymer chains	3
Total formula weight	150668.92
Authors	Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U. (deposition date: 2014-02-13, release date: 2014-12-10, Last modification date: 2023-09-27)
Primary citation	Chitnumsub, P.,Jaruwat, A.,Riangrungroj, P.,Ittarat, W.,Noytanom, K.,Oonanant, W.,Vanichthanankul, J.,Chuankhayan, P.,Maenpuen, S.,Chen, C.J.,Chaiyen, P.,Yuthavong, Y.,Leartsakulpanich, U. Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control. Acta Crystallogr.,Sect.D, 70:3177-3186, 2014 Cited by PubMed: 25478836 DOI: 10.1107/S1399004714023128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation