4OYT
Crystal structure of ternary complex of Plasmodium vivax SHMT with D-serine and folinic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 1W9 A 501 |
| Chain | Residue |
| A | SER34 |
| A | HIS236 |
| A | LYS237 |
| A | ARG371 |
| A | FON502 |
| A | HOH664 |
| B | TYR54 |
| B | GLU56 |
| B | TYR64 |
| B | GLY272 |
| B | HOH613 |
| A | SER100 |
| A | GLY101 |
| A | SER102 |
| A | HIS129 |
| A | THR183 |
| A | ASP208 |
| A | HIS211 |
| A | THR234 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue FON A 502 |
| Chain | Residue |
| A | LEU124 |
| A | GLY127 |
| A | GLY128 |
| A | HIS129 |
| A | LEU130 |
| A | VAL141 |
| A | THR183 |
| A | CYS364 |
| A | 1W9501 |
| A | GOL504 |
| A | HOH667 |
| B | GLU56 |
| B | TYR63 |
| B | TYR64 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | SER126 |
| A | GLY159 |
| A | SER184 |
| A | TYR185 |
| A | VAL319 |
| A | VAL329 |
| A | THR357 |
| A | ILE358 |
| A | HOH613 |
| A | HOH645 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | LYS355 |
| A | ASN356 |
| A | THR357 |
| A | CYS364 |
| A | FON502 |
| A | HOH666 |
| A | HOH667 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue 1W9 B 501 |
| Chain | Residue |
| A | TYR54 |
| A | GLU56 |
| A | TYR64 |
| A | GLY272 |
| A | HOH637 |
| B | SER34 |
| B | SER100 |
| B | GLY101 |
| B | SER102 |
| B | HIS129 |
| B | THR183 |
| B | ASP208 |
| B | HIS211 |
| B | THR234 |
| B | HIS236 |
| B | LYS237 |
| B | ARG371 |
| B | FON502 |
| B | HOH615 |
| B | HOH620 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue FON B 502 |
| Chain | Residue |
| A | GLU56 |
| A | TYR63 |
| A | TYR64 |
| B | LEU124 |
| B | GLY127 |
| B | GLY128 |
| B | HIS129 |
| B | LEU130 |
| B | THR183 |
| B | 1W9501 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| A | ALA103 |
| A | HOH682 |
| B | LEU99 |
| B | ALA103 |
| B | GLN107 |
| B | PHE269 |
| B | GLN270 |
| B | HOH666 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for residue 1W9 C 501 |
| Chain | Residue |
| C | THR234 |
| C | HIS236 |
| C | LYS237 |
| C | GLY272 |
| C | ARG371 |
| C | FON502 |
| C | HOH604 |
| C | HOH620 |
| C | HOH621 |
| C | SER34 |
| C | TYR54 |
| C | GLU56 |
| C | TYR64 |
| C | SER100 |
| C | GLY101 |
| C | SER102 |
| C | HIS129 |
| C | THR183 |
| C | ASP208 |
| C | HIS211 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue FON C 502 |
| Chain | Residue |
| C | GLU56 |
| C | TYR63 |
| C | TYR64 |
| C | LEU124 |
| C | GLY127 |
| C | GLY128 |
| C | HIS129 |
| C | LEU130 |
| C | THR183 |
| C | 1W9501 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue TRS C 503 |
| Chain | Residue |
| C | CYS125 |
| C | SER126 |
| C | GLY127 |
| C | CYS155 |
| C | GLY159 |
| C | SER184 |
| C | PRO186 |
| C | VAL319 |
| C | VAL329 |
| C | ASN356 |
| C | THR357 |
| C | ILE358 |
| C | HOH643 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ETF C 504 |
| Chain | Residue |
| C | GLN78 |
| C | GLY93 |
| C | VAL94 |
| C | GLU258 |
| C | ASN262 |
| C | HOH661 |
