4NUA

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Summary for 4NUA

• Entry DOI: 10.2210/pdb4nua/pdb
• Related: 1YQ7 4N9U 4NG6 4NKE 4NKF
• Descriptor: Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: cholesterol synthesis, alpha-helical prenyltransferase fold, transferase, isoprene synthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, dimethylallyl pyrophosphate, isopentenyl pyrophosphate
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43894.26

Authors

Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (deposition date: 2013-12-03, release date: 2014-11-19, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; To be Published,

Experimental method

X-RAY DIFFRACTION (1.43 Å)