4NUA

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

4NUA の概要

• エントリーDOI: 10.2210/pdb4nua/pdb
• 関連するPDBエントリー: 1YQ7 4N9U 4NG6 4NKE 4NKF
• 分子名称: Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: cholesterol synthesis, alpha-helical prenyltransferase fold, transferase, isoprene synthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, dimethylallyl pyrophosphate, isopentenyl pyrophosphate
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43894.26

構造登録者

Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (登録日: 2013-12-03, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; To be Published,

実験手法

X-RAY DIFFRACTION (1.43 Å)